rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular diversity in drug design
  name:
    name part: Dean, P. M. (Philip Michael)
    name part: 1944-
  name:
    name part: Lewis, Richard A.
  type of resource: text
  genre: bibliography
  genre: Electronic books.
  origin info:
    place:
      place term: ne
    place:
      place term: Dordrecht, the Netherlands
    place:
      place term: Boston
    publisher: Kluwer Academic Publishers
    date issued: �1999
    date issued: 1999
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: remote
    extent: 1 online resource (xiv, 253 pages) : illustrations
  abstract: This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry. Therefore, this book deals with algorithms that are involved in understanding chemical space and selection of diverse sets of structures. The algorithms also deal with the problem of focused diversity where chemical libraries are being created within a structured physical volume. Diversity is necessarily connected to combinational chemistry, although this book is limited to the application of diversity methods to combinational chemistry and does not deal with synthetic methods. It is this focus on algorithms and strategies for exploiting molecular diversity that makes it different from books on combinational chemistry. The intended readership of the book falls into two categories: those actively engaged in applying molecular diversity in the chemical industry and those in academia who are developing strategies to embrace, understand and accept the many problems thrown up by this new research field of molecular diversity.
  table of contents: Issues in molecular diversity and the role of ligand binding sites / James Smith, Philip M. Dean and Richard A. Lewis -- Molecular diversity in drug design : application to high-speed synthesis and high-throughput screening / Christopher G. Newton -- Background theory of molecular diversity / Valerie J. Gillet -- Absolute vs relative similarity and diversity / Jonathan S. Mason -- Diversity in very large libraries / Lutz Weber and Michael Almstetter -- Subset-selection methods for chemical databases / P. Willett -- Molecular diversity in site-focused libraries / Diana C. Roe -- Managing combinatorial chemistry information / Keith Davies and Catherine White -- Design of small libraries for lead exploration / Per M. Andersson [and others] -- The design of small- and medium-sized focused combinatorial libraries / Richard A. Lewis.
  note: edited by Philip M. Dean and Richard A. Lewis.
  note: Includes bibliographical references and index.
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Pharmaceutical chemistry
  subject:
    topic: Molecular biology
  subject:
    topic: Drugs
    topic: Structure-activity relationships
  subject:
    topic: Combinatorial chemistry
  subject:
    topic: Drug Design
  subject:
    topic: Chemistry, Pharmaceutical
  subject:
    topic: Molecular Biology
  subject:
    topic: Structure-Activity Relationship
  subject:
    topic: MEDICAL
    topic: Drug Guides
  subject:
    topic: MEDICAL
    topic: Pharmacology
  subject:
    topic: MEDICAL
    topic: Pharmacy
  subject:
    topic: MEDICAL
    topic: Nursing
    topic: Pharmacology
  subject:
    topic: Combinatorial chemistry
  subject:
    topic: Drugs
    topic: Design
  subject:
    topic: Drugs
    topic: Structure-activity relationships
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmaceutical chemistry
  classification: RS420 .M64 1999eb
  classification: 615.19
  classification: QV 744 M7167 1999
  related item:
    title info:
      title: Molecular diversity in drug design
    origin info:
      publisher: Dordrecht, the Netherlands ; Boston : Kluwer Academic Publishers, �1999
    identifier: (DLC) 99046325
    identifier: (OCoLC)42292246
  identifier: 0306468735
  identifier: 9780306468735
  identifier: 0792359801
  identifier: 9780792359807
  identifier: 6610043361
  identifier: 9786610043361
  identifier: 99046325
  identifier: http://search.ebscohost.com/login.aspx
  record info:
    record content source: N$T
    record creation date: 030502
    record change date: 20190114101357.0
    record identifier: ocm52171098
    language of cataloging:
      language term: eng