rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Human Cell Culture
    sub title: Cancer Cell Lines Part 2
  name:
    name part: Masters, John R. W.
    role:
      role term: editor.
  name:
    name part: Palsson, Bernhard.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2002
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 377 p. online resource.
  abstract: Continuous cell lines derived from human cancers are the mostwidely used resource in laboratory-based cancer research. The first 3 volumes of this series on Human Cell Culture are devoted to these cancer cell lines. The chapters in these first 3 volumes have a common aim. Their purpose is to address 3 questions offundamental importance to the relevanceof human cancer cell lines as model systems of each type of cancer: 1. Do the cell lines available accurately represent the clinical presentation? 2. Do the cell lines accurately represent the histopathology of the original tumors? 3. Do the cell lines accurately represent the molecular genetics of this type of cancer? The cancer cell lines available are derived, in most cases, from the more aggressive and advanced cancers. There are few cell lines derived from low grade organ-confined cancers. This gap can be filled with conditionally immortalized human cancer cell lines. We do not know why the success rate for establishing cell lines is so low for some types of cancer and so high for others. The histopathology of the tumor of origin and the extent to which the derived cell line retains the differentiated features of that tumor are critical. The concept that a single cell line derived from a tumor at a particular site is representative oftumors at that site is naïve and misleading.
  table of contents: Ovarian Cancer -- Cervical Cancer -- Endometrial Cancer -- Breast Cancer -- Paired Breast Cancer Cell Lines -- Ovarian Germ Cell Tumors -- Testicular Germ Cell Tumors -- Choriocarcinoma -- Thymomas and Thymic Cancers -- Kaposi’s Sarcoma -- Brain Tumors -- Head and Neck Cancers -- Gastric Cancer -- Colorectal Cancer -- Prostate Cancer -- Liver Cancer -- Wilms’ Tumor and Other Childhood Renal Neoplasms -- Retinoblastoma.
  note: edited by John R. W. Masters, Bernhard Palsson.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Internal medicine
  subject:
    topic: Oncology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Cell Biology
  subject:
    topic: Oncology
  subject:
    topic: Internal Medicine
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Human Cell Culture, 2
  identifier: 9780306468612
  identifier: http://dx.doi.org/10.1007/0-306-46861-1
  record info:
    record creation date: 100301
    record change date: 20151204141955.0
    record identifier: 978-0-306-46861-2