rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Multiple Analyses in Clinical Trials
    sub title: Fundamentals for Investigators
  name:
    name part: Moyé, Lemuel A.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2003
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXIV, 436 p. online resource.
  abstract: One of the most challenging issues for clinical trial investigators, sponsors, and regulatory officials is the interpretation of experimental results that are composed of the results of multiple statistical analyses. These analyses may include the effect of therapy on multiple endpoints, the assessment of a subgroup analysis, and the evaluation of a dose-response relationship in complex mixtures. Multiple Analyses in Clinical Trials: Fundamentals for Clinical Investigators is an essentially nonmathematical discussion of the problems posed by the execution of multiple analyses in clinical trials. It concentrates on the rationale for the analyses, the difficulties posed by their interpretation, easily understood solutions, and useful problem sets. This text will help clinical investigators understand multiple analysis procedures and the key issues when designing their own work or reviewing the research of others. This book is written for advanced medical students, clinical investigators at all levels, research groups within the pharmaceutical industry, regulators at the local, state, and federal level, and biostatisticians. Only a basic background in health care and introductory statistics is required. Dr. Lemuel A. Moyé, M.D., Ph.D. is a physician and Professor of Biometry at the University of Texas School of Public Health. He has been Co-Principal Investigator of two multinational clinical trials examining the role of innovative therapy in post myocardial infarction survival (SAVE) and the use of cholesterol reducing agents in post myocardial infarction survival in patients with normal cholesterol levels (CARE). He has authored over one hundred articles in journals such as the Journal of the American Medical Association, the New England Journal of Medicine, Statistics in Medicine, and Controlled Clinical Trials. From the reviews: From the reviews: "A quick scan of the book indicates that it is not a typical statistics book…You can jump in almost anywhere and just st…
  table of contents: Prologue -- Fundamentals of Clinical Trial Design -- Multiple Analyses and the Random Experiment -- The Lure and Complexity of Multiple Analyses -- Multiple Analyses and Multiple Endpoints -- to Multiple Dependent Analyses I -- Multiple Dependent Analyses II -- to Composite Endpoints -- Multiple Analyses and Composite Endpoints -- to Subgroup Analyses -- Subgroups II: Effect Domination and Controversy -- Subgroups III: Confirmatory Analyses -- Multiple Analyses and Multiple Treatment Arms -- Combining Multiple Analyses -- Conclusions: The Two-Front War.
  note: by Lemuel A. Moyé.
  subject:
    topic: Medicine
  subject:
    topic: Statistics
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  subject:
    topic: Statistics for Life Sciences, Medicine, Health Sciences
  subject:
    topic: Medicine/Public Health, general
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Statistics for Biology and Health
  identifier: 9780387218137
  identifier: http://dx.doi.org/10.1007/b97513
  record info:
    record creation date: 100301
    record change date: 20151204145948.0
    record identifier: 978-0-387-21813-7