rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Viral Membrane Proteins: Structure, Function, and Drug Design
  name:
    name part: Fischer, Wolfgang B.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2005
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 292 p. 98 illus. online resource.
  abstract: Protein Reviews, a new book series from Springer, covers all aspects of protein investigations including protein chemistry, sequence, 3-D structure, biological activity, proteomics, methodology, and many more new and emerging topics. Volume 1: Viral Membrane Proteins: Structure, Function and Drug Design Edited by Wolfgang B. Fischer This volume, written by renowned leaders in the field, summarizes the current structural and functional knowledge of membrane proteins encoded by viruses while addressing questions about the proteins as potential drug targets. Early praise for this volume: "We all know that you can't treat viral disease with drugs.....That was what all physicians and scientists were taught for decades with conviction but without enough experiments. Fortunately, we were taught wrong: rationally designed drugs are available that work well against influenza as Garman and Laver describe so well (with the help of Wen Yang Wu) in a fascinating chapter of this book. In fact, viral membrane proteins have a range of functions of great medical and biological importance, not so surprisingly if one understands that membrane proteins control a wide range of function because they are gatekeepers for cells. Membrane proteins control entry into cells and viruses. Viral Membrane Proteins" is a wonderful description of some of these proteins. The authors and editor are to be congratulated on producing much more than a collection of reviews and essays. This book can help teach everyone that it is possible to treat viral disease with drugs that bind to membrane proteins. Knowing that, we can hope that more resources will be focused on finding other such drugs to the remaining scourges of mankind, at least those we do not produce ourselves." - Robert S. Eisenberg, Rush University Medical Center, Chicago, IL < .
  table of contents: Membrane Proteins from Plant Viruses -- Membrane Proteins in Plant Viruses -- Structure and Function of a Viral Encoded K+ Channel -- Fusion Proteins -- HIV gp41: A Viral Membrane Fusion Machine -- Diversity of Coronavirus Spikes: Relationship to Pathogen Entry and Dissemination -- Aspects of the Fusogenic Activity of Influenza Hemagglutinin Peptides by Molecular Dynamics Simulations -- Viral Ion Channels/viroporins -- Viral Proteins that Enhance Membrane Permeability -- FTIR Studies of Viral Ion Channels -- The M2 Proteins of Influenza A and B Viruses are Single-Pass Proton Channels -- Influenza A Virus M2 Protein: Proton Selectivity of the Ion Channel, Cytotoxicity, and a Hypothesis on Peripheral Raft Association and Virus Budding -- Computer Simulations of Proton Transport Through the M2 Channel of the Influenza A Virus -- Structure and Function of Vpu from HIV-1 -- Structure, Phosphorylation, and Biological Function of the HIV-1 Specific Virus Protein U (Vpu) -- Solid-State NMR Investigations of Vpu Structural Domains in Oriented Phospholipid Bilayers: Interactions and Alignment -- Defining Drug Interactions with the Viral Membrane Protein Vpu from HIV-1 -- Virus Ion Channels Formed by Vpu of HIV-1, the 6K Protein of Alphaviruses and NB of Influenza B Virus -- The Alphavirus 6K Protein -- Membrane-Spanning/Membrane Associated -- The Structure, Function, and Inhibition of Influenza Virus Neuraminidase -- Interaction of HIV-1 Nef with Human CD4 and Lck.
  note: edited by Wolfgang B. Fischer.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Pharmacology
  subject:
    topic: Virology
  subject:
    topic: Biochemistry
  subject:
    topic: Microbiology
  subject:
    topic: Biomedicine
  subject:
    topic: Virology
  subject:
    topic: Immunology
  subject:
    topic: Biochemistry, general
  subject:
    topic: Microbiology
  subject:
    topic: Pharmacology/Toxicology
  classification: QR355-502
  classification: 616.9101
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Protein Reviews ; 1
  identifier: 9780387281469
  identifier: http://dx.doi.org/10.1007/0-387-28146-0
  record info:
    record creation date: 100301
    record change date: 20151103125330.0
    record identifier: 978-0-387-28146-9