rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Lysosomes
  name:
    name part: Saftig, Paul.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2005
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 197 p. online resource.
  abstract: Lysosomes are membrane-surrounded organelles which are present in all animal cells. The importance of this organelle is underlined by an increasing number of human diseases, which are associated with an impaired function of the lysosomal compartment. This book summarizes the current state-of-the art knowledge about this unique organelle. It addresses the biogenesis of this compartment, the transport of lysosomal proteins, the role of the lysosomal membrane in lysosomal stability and transport, the function of lysosomal proteases and hydrolases, lysosomal storage disorders, and new concepts on how to treat these diseases. In addition to these classical topics, new insights into lysosomal functions are covered by chapters dealing with specialized lysosomes involved in bone resorption and plasma membrane repair, the lysosomal transciptome, and proteome and the emerging role of lysosomes in special forms of autophagy. This book will provide readers with a comprehensive overview into how this fascinating organelle works and how research in the field is developing.
  table of contents: History and Morphology of the Lysosome -- Transport of Lysosomal Enzymes -- Adaptor Proteins in Lysosomal Biogenesis -- Lysosomal Membrane Proteins -- Lysosomal Proteases -- Lysosomal Storage Disorders -- Lysosomal Transporters and Associated Diseases -- Neuronal Ceroid-Lipofuscinoses -- Cholesterol Transport in Lysosomes -- Therapy of Lysosomal Storage Diseases -- Lysosomal Proteome and Transcriptome -- External Lysosomes -- Membrane Resealing Mediated by Lysosomal Exocytosis -- Macroautophagy in Mammalian Cells -- Chaperone-Mediated Autophagy.
  note: by Paul Saftig.
  subject:
    topic: Life sciences
  subject:
    topic: Human genetics
  subject:
    topic: Neurosciences
  subject:
    topic: Biochemistry
  subject:
    topic: Cell biology
  subject:
    topic: Life Sciences
  subject:
    topic: Cell Biology
  subject:
    topic: Biochemistry, general
  subject:
    topic: Human Genetics
  subject:
    topic: Neurosciences
  classification: QH573-671
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Medical Intelligence Unit
  identifier: 9780387289571
  identifier: http://dx.doi.org/10.1007/0-387-28957-7
  record info:
    record creation date: 100301
    record change date: 20151204145121.0
    record identifier: 978-0-387-28957-1