rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Sigma Receptors
    sub title: Chemistry, Cell Biology and Clinical Implications
  name:
    name part: Su, Tsung-Ping.
    role:
      role term: editor.
  name:
    name part: Matsumoto, Rae R.
    role:
      role term: editor.
  name:
    name part: Bowen, Wayne D.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2007
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 413 p. online resource.
  abstract: Sigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic receptors, or receptor tyrosine kinases. With two subtypes currently known, they modulate cell survival and excitability, and subserve many critical functions in the body. Endogenous ligands for these receptors are unknown, though current clues point to neurosteroids. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of sigma receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point for the development of exciting, new research. Sigma Receptors: Chemistry, Cell Biology and Clinical Implications will be a valuable tool for pharmacologists, medicinal chemists, cell biologists, molecular biologists, clinicians, and others interested in a concise, state-of-the-art overview of the sigma receptor field with a particular view towards novel therapeutic advances.
  table of contents: ? Receptors: Historical Perspective and Background -- Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands -- Irreversible ? Compounds -- Pharmacophore Models for ?1 Receptor Binding -- Cloning of ?1 Receptor and Structural Analysis of Its Gene and Promoter Region -- Site-Directed Mutagenesis -- ? Receptor Modulation of Ion Channels -- Subcellular Localization and Interacellular Dynamics of ?1 Receptors -- Intracellular Signaling and Synaptic Plasticity -- Modulation of Classical Neurotransmitter Systems by ? Receptors -- ?2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics -- Cognitive Effects of ? Receptor Ligands -- ? Receptors and Scizophrenia -- Potential Role of ? Ligands and Neurosteroids in Major Depression -- ? Receptors and Drug Abuse -- ?1 Receptors and the Modulation of Opiate Analgesics -- ? Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview -- ? Receptors and Gastrointestinal Function.
  note: edited by Tsung-Ping Su, Rae R. Matsumoto, Wayne D. Bowen.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Chemistry
  subject:
    topic: Psychiatry
  subject:
    topic: Biochemistry
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Chemistry/Food Science, general
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Biochemistry, general
  subject:
    topic: Cell Biology
  subject:
    topic: Psychiatry
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  identifier: 9780387365145
  identifier: http://dx.doi.org/10.1007/978-0-387-36514-5
  record info:
    record creation date: 100301
    record change date: 20151204171423.0
    record identifier: 978-0-387-36514-5