rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Acute Myelogenous Leukemia
    sub title: Genetics, Biology and Therapy
  name:
    name part: Nagarajan, Lalitha.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    edition: 1.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: IX, 280 p. online resource.
  abstract: Acute myelogenous leukemia (AML), is the most common form of leukemia in adults. AML is a deadly form of malignancy, the prognosis for which has not improved in the last two decades. More importantly, it is a malignancy that is seen in older adults, therefore the number of cases is likely to rise as the population ages. Over the past 15 years, genetic mechanisms underlying AML have begun to unfold. Additional research in this area has helped identify key components and characteristics. Consequently, targeted therapy of AML is receiving much attention. It is the hope of researchers that as with chronic myelogenous leukemia (CML), and the drug, Gleevec, a targeted therapy for AML will be discovered. "The effective treatment of acute myelogenous leukemia remains a great challenge. This text reviews our understanding of the molecular and biologic basis of the disease. Leading investigators address advances in prognostication and therapeutic strategies that have significant promise." Steven T. Rosen, M.D. Series Editor.
  table of contents: The Leukemia Stem Cell -- Epigenetic Mechanisms in AML – A Target for Therapy -- Chromosomal Translocations in AML: Detection and Prognostic Significance -- Chromosomal Deletions in AML -- Genes Predictive of Outcome and Novel Molecular Classification Schemes in Adult Acute Myeloid Leukemia -- Receptor Tyrosine Kinase Alterations in AML – Biology and Therapy -- Lineage-Specific Transcription Factor Aberrations in AML -- Proleukemic RUNX1 and CBF? Mutations in the Pathogenesis of Acute Leukemia -- Acute Myeloid Leukemia with Mutated Nucleophosmin (NPM1): Molecular, Pathological, and Clinical Features -- MicroRNAs: New Players in AML Pathogenesis -- Murine Models of Human Acute Myeloid Leukemia -- Apoptosis in Leukemias: Regulation and Therapeutic Targeting -- Acute Promyelocytic Leukemia: A Paradigm for Differentiation Therapy -- Immunotherapy of AML -- Therapy of Acute Myelogenous Leukemia in Adults.
  note: edited by Lalitha Nagarajan.
  subject:
    topic: Medicine
  subject:
    topic: Hematology
  subject:
    topic: Oncology
  subject:
    topic: System theory
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Oncology
  subject:
    topic: Hematology
  subject:
    topic: Systems Theory, Control
  classification: RC254-282
  classification: 616.994
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Cancer Treatment and Research, 145
  identifier: 9780387692593
  identifier: http://dx.doi.org/10.1007/978-0-387-69259-3
  record info:
    record creation date: 100715
    record change date: 20151204165306.0
    record identifier: 978-0-387-69259-3