rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Handbook of Single-Molecule Biophysics
  name:
    name part: Hinterdorfer, Peter.
    role:
      role term: editor.
  name:
    name part: Oijen, Antoine.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXI, 626 p. online resource.
  abstract: The last decade has seen the development of a number of novel biophysical methods that allow the manipulation and study of individual biomolecules. The ability to monitor biological processes at this fundamental level of sensitivity has given rise to an improved understanding of the underlying molecular mechanisms. Through the removal of ensemble averaging, distributions and fluctuations of molecular properties can be characterized, transient intermediates identified, and catalytic mechanisms elucidated. By applying forces on biomolecules while monitoring their activity, important information can be obtained on how proteins couple function to structure. The Handbook of Single-Molecule Biophysics provides an introduction to these techniques and presents an extensive discussion of the new biological insights obtained from them. Coverage includes: Experimental techniques to monitor and manipulate individual biomolecules The use of single-molecule techniques in super-resolution and functional imaging Single-molecule studies of physical properties of biomolecules Single-molecule enzymology and biochemistry Single molecules in the membrane Single-molecule techniques in living cells Integration of single-molecule biophysics and nanoscience.
  table of contents: Single-Molecule Fluorescent Particle Tracking -- Single-Molecule Analysis of Biomembranes -- Single-Molecule Imaging in Live Cells -- Fluorescence Imaging at Sub-Diffraction-Limit Resolution with Stochastic Optical Reconstruction Microscopy -- Single-Molecule FRET: Methods and Biological Applications -- Single-Molecule Enzymology -- Single-Molecule Studies of Rotary Molecular Motors -- Fluorescence Correlation Spectroscopy in Living Cells -- Precise Measurements of Diffusion in Solution by Fluorescence Correlations Spectroscopy -- Single-Molecule Studies of Nucleic Acid Interactions Using Nanopores -- Nanopores: Generation, Engineering, and Single-Molecule Applications -- Single-Molecule Manipulation Using Optical Traps -- Magnetic Tweezers for Single-Molecule Experiments -- Folding of Proteins under Mechanical Force -- Probing the Energy Landscape of Protein-Binding Reactions by Dynamic Force Spectroscopy -- Probing Single Membrane Proteins by Atomic Force Microscopy -- High-Speed Atomic Force Microscopy -- Recognition Imaging Using Atomic Force Microscopy -- Atomic Force Microscopy of Protein–Protein Interactions -- A New Approach to Analysis of Single-Molecule Force Measurements -- Single-Molecule Recognition: Extracting Information from Individual Binding Events and Their Correlation.
  note: edited by Peter Hinterdorfer, Antoine Oijen.
  subject:
    topic: Physics
  subject:
    topic: Molecular biology
  subject:
    topic: Life sciences
  subject:
    topic: Biophysics
  subject:
    topic: Biological physics
  subject:
    topic: Lasers
  subject:
    topic: Photonics
  subject:
    topic: Biomedical engineering
  subject:
    topic: Nanotechnology
  subject:
    topic: Physics
  subject:
    topic: Biophysics and Biological Physics
  subject:
    topic: Life Sciences, general
  subject:
    topic: Molecular Medicine
  subject:
    topic: Laser Technology, Photonics
  subject:
    topic: Biomedical Engineering
  subject:
    topic: Nanotechnology
  classification: QH505
  classification: 571.4
  related item:
    title info:
      title: Springer eBooks
  identifier: 9780387764979
  identifier: http://dx.doi.org/10.1007/978-0-387-76497-9
  record info:
    record creation date: 100301
    record change date: 20151204180656.0
    record identifier: 978-0-387-76497-9