rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mitochondria and Cancer
  name:
    name part: Costello, Leslie.
    role:
      role term: editor.
  name:
    name part: Singh, Keshav.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 289 p. 46 illus., 7 illus. in color. online resource.
  abstract: Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial metabolic activity, molecular composition of mitochondria and mtDNA sequence, as well as in alteration of nuclear genes encoding mitochondrial proteins. This book, Mitochondria and Cancer, edited by Keshav K. Singh and Leslie C. Costello, presents thorough analyses of mitochondrial dysfunction as one of the hallmarks of cancer, discusses the clinical implications of mitochondrial defects in cancer, and as unique cellular targets for novel and selective anti-cancer therapy.
  table of contents: Mitochondria and Cancer -- Warburg and his Legacy -- The Lipogenic Switch in Cancer -- Citrate Metabolism in Prostate and Other Cancers -- Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism -- Mitochondrial Respiration and Differentiation -- Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells -- Energy Generating Pathways and the Tumor Suppressor p53 -- Mitochondrial Tumor Suppressors -- Mitochondria in Hematology -- Mitochondria and Oncocytomas -- Mitochondria as Targets for Cancer Therapy -- Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy -- Mitochondrial Nanotechnology for Cancer Therapy.
  note: edited by Leslie Costello, Keshav Singh.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Laboratory medicine
  subject:
    topic: Medical microbiology
  subject:
    topic: Molecular biology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Medical Microbiology
  subject:
    topic: Molecular Medicine
  subject:
    topic: Cell Biology
  subject:
    topic: Biomedicine general
  subject:
    topic: Laboratory Medicine
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9780387848358
  identifier: http://dx.doi.org/10.1007/978-0-387-84835-8
  record info:
    record creation date: 100715
    record change date: 20151125201649.0
    record identifier: 978-0-387-84835-8