rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Genetic Engineering of Mesenchymal Stem Cells
  name:
    name part: Nolta, Jan A.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: VI, 170 p. online resource.
  abstract: MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.
  table of contents: Mesenchymal Stem Cell Engineering and Transplantation -- Establishment and Transduction of Primary Human Stromal/Mesenchymal Stem Cell Monolayers -- Gene Expression Profiles of Mesenchymal Stem Cells -- In Vivo Homing and Regeneration of Freshly Isolated and Cultured Murine Mesenchymal Stem Cells -- Non-Human Primate Models of Mesenchymal Stem Cell Transplantation -- Engineering of Human Adipose-Derived Mesenchymal Stem-Like Cells -- Uncommitted Progenitors in Cultures of Bone Marrow-Derived Mesenchymal Stem Cells -- Bone Marrow Mesenchymal Stem Cell Transplantation for Children with Severe Osteogenesis Imperfecta -- Clinical Trials of Human Mesenchymal Stem Cells to Support Hematopoietic Stem Cell Transplantation.
  note: edited by Jan A. Nolta.
  subject:
    topic: Life sciences
  subject:
    topic: Hematology
  subject:
    topic: Surgical transplantation
  subject:
    topic: Cell biology
  subject:
    topic: Animal physiology
  subject:
    topic: Life Sciences
  subject:
    topic: Cell Biology
  subject:
    topic: Biomedicine general
  subject:
    topic: Hematology
  subject:
    topic: Transplant Surgery
  subject:
    topic: Animal Physiology
  classification: QH573-671
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781402039591
  identifier: http://dx.doi.org/10.1007/1-4020-3959-X
  record info:
    record creation date: 100301
    record change date: 20151204173928.0
    record identifier: 978-1-4020-3959-1