rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: RAS Family GTPases
  name:
    name part: Der, Channing.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 396 p. online resource.
  abstract: Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of oncogenesis and targets for anti-cancer drug discovery. Second, Ras proteins act as signalling nodes activated by diverse extracellular stimuli, and activated Ras in turn regulates a diversity of cytoplasmic signalling networks. Third, Ras proteins are founding members of a large superfamily of Ras-related small GTPases. Over 150 Ras-related small GTPases are found in the human genome, with orthologs found in all vertebrate species and invertebrates. This book features chapters by leading investigators in the field that highlight the current state-of-the art in Ras biochemistry, structure and biology. This book is an excellent reference for students in the biomedical sciences and for investigators in the field.
  table of contents: Ras Stories: The State of the Art -- Ras-Gefs and Ras Gaps -- Structural Principles of Ras Interaction with Regulators and Effectors -- RAS and the RAF/MEK/ERK Cascade -- Noncanonical Effector Targets Of Oncogenic Ras Proteins -- Effectors of Ras-Mediated Oncogenesis -- RHO Proteins in RAS Signaling and Transformation -- Global Effects of Ras Signaling on the Genetic Program in Mammalian Cells -- Ras Signaling in C. Elegans -- Ras Family G-Proteins in Saccharomyces Cerevisiae and Schizosaccharomyces Pombe -- Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells -- Genetically Engineered Mice Harboring RAS Mutations as Models of Human Cancer: in Medias RAS -- Ras Family Proteins -- #x003BA;B-RAS: A Small Gtpase That Influences NF-#x003BA;B Signaling -- Anti-Ras Strategies for Cancer Treatment.
  note: edited by Channing Der.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human physiology
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmacology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Human Physiology
  subject:
    topic: Molecular Medicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Cell Biology
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Proteins and Cell Regulation ; 4
  identifier: 9781402047084
  identifier: http://dx.doi.org/10.1007/1-4020-4708-8
  record info:
    record creation date: 100301
    record change date: 20151204175505.0
    record identifier: 978-1-4020-4708-4