rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Handbook on Immunosenescence
    sub title: Basic Understanding and Clinical Applications
  name:
    name part: Fulop, Tamas.
    role:
      role term: editor.
  name:
    name part: Franceschi, Claudio.
    role:
      role term: editor.
  name:
    name part: Hirokawa, Katsuiku.
    role:
      role term: editor.
  name:
    name part: Pawelec, Graham.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: ne
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXXI, 1655 p. online resource.
  abstract: “Immunosenescence” is an imprecise term used to describe deleterious age-associated changes to immune parameters observed in all mammals studied so far. It represents a rapidly progressing science in the aging field, with a vertiginous volume of new data, knowledge and concepts concerning these changes. We are poised to be in a position to translate these accumulated data into the clinical setting via better understanding of the contribution of immunosenescence to age-associated pathologies, and their prevention by appropriate interventions. This authoritative handbook seeks to encompass the current state of our knowledge on the multitude of those changes to immunity related to aging, with contributions from experts in the research and clinical areas. This book therefore considers methods and models for studying immunosenescence; cellular immunosenescence of T cells, B cells, neutrophils, antigen presenting cells, NK, NKT and stem cells; genetics; mechanisms including receptors and signal transduction; mitochondria; proteasome; cytokines; neuro-endocrine-immune networks; inflammation; thymus; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; modulation by nutrition, lipids, vaccination and the question “can interventions to influence immunosenescence be realistically proposed based on our current state of knowledge?”.
  table of contents: 1. Immunosenescence -- 2. Methods and models for studying immunosenescence -- 3. Cellular immunosenescence. 3.1 T cells. 3.2. B cells. 3.3 Neutrophils. 3.4 Antigen presenting cells. 3.5 NK and NKT cells. 3.6. Stem cells. 3.7. Genetics -- 4. Mechanisms 4.1. Receptors and signal transduction. 4.2 Mitochondria. 4.3 Proteasome. 4.4 Cytokines. 4.5 Neuro-endocrine-immune Network. 4.6 Thymus. 4.7. Inflammation -- 5. Clinical relevance in disease states. 5.1 Infection. 5.2 Autoimmunity. 5.3 Cancer. 5.4 Metabolic syndrome. 5.5. Neurodegenerative diseases. 5.6 Frailty. 5.7. Osteoporosis -- 6. Modulation. 6.1 Nutrition. 6.2. Lipids. 6.3. Vaccination. 6.4. Can interventions to influence immunosenescence succeed? Subject Index.
  note: edited by Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Geriatrics
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  subject:
    topic: Immunology
  subject:
    topic: Geriatrics/Gerontology
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781402090639
  identifier: http://dx.doi.org/10.1007/978-1-4020-9063-9
  record info:
    record creation date: 100301
    record change date: 20150520190454.0
    record identifier: 978-1-4020-9063-9