rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Synaptic Plasticity in Pain
  name:
    name part: Malcangio, Marzia.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2009
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 504 p. online resource.
  abstract: Primary sensory neurons respond to peripheral stimulation by projecting to the spinal cord, where a population of neurons respond to damaging stimuli and terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second-order neurons. It has recently become clear, however, that the strength of this first pain synapse is plastic and modifiable by several modulators--including neuronal and non-neuronal regulators--and studies on the fundamental processes regulating this plasticity have resulted in the identification of new targets for the treatment of chronic pain. With special emphasis on neuropathic pain, Synaptic Plasticity in Pain examines these targets and mechanisms for chronic pain in the dorsal horn, providing up-to-date research from the world's foremost pain experts. The book also delineates anatomical circuits for pain in the dorsal horn, explores the fast and slow transmissions at the pain synapse, and discusses how synaptic plasticity can be monitored in the dorsal horn during pain transmission. Synaptic Plasticity in Pain is published at a time of intensive experimental research aimed at finding new mechanisms and targets for the treatment of chronic pain. This book will be of importance to a wide readership in the pain field including PhD students, doctoral scientists, and academics. It will also appeal to scientists who are interested in synaptic plasticity associated with other CNS functions, and to private sector drug discovery teams, who will find solid scientific support to their research in these pages. About the Editor: Dr. Marzia Malcangio holds a Bachelors' degree in pharmaceutical chemistry and a PhD in Pharmacology from the University of Florence, Italy. She spent most of her active scientific life in London,UK, establishing an internationally renowned laboratory devoted to the biology of spinal cord mechanisms underlying…
  table of contents: Anatomical Plasticity of Dorsal Horn Circuits -- Changes in NK1 and Glutamate Receptors in Pain -- Trophic Factors and Their Receptors in Pain Pathways -- Fast Synaptic Transmission in the Dorsal Horn -- Fast Inhibitory Transmission of Pain in the Spinal Cord -- Synaptic Transmission of Pain in the Developing Spinal Cord -- Slow Synaptic Transmission in the Dorsal Horn -- BDNF and TrkB Mediated Mechanisms in the Spinal Cord -- Dorsal Horn Substance P and NK1 Receptors: Study of a Model System in Spinal Nociceptive Processing -- Opioidergic Transmission in the Dorsal Horn -- CGRP in Spinal Cord Pain Mechanisms -- Amplification of Pain-Related Information -- Long-Term Potentiation in Superficial Spinal Dorsal Horn: A Pain Amplifier -- Modulation of Long-Term Potentiation of Excitatory Synaptic Transmission in the Spinal Cord Dorsal Horn -- Windup in the Spinal Cord -- Mechanisms and Targets for Chronic Pain -- Pain from the Arthritic Joint -- Spinal Mechanisms of Visceral Pain and Hyperalgesia -- Descending Modulation of Pain -- Cannabinoid Receptor Mediated Analgesia: Novel Targets for Chronic Pain States -- Spinal Dynorphin and Neuropathic Pain -- Microglia, Cytokines and Pain -- The Role of Astrocytes in the Modulation of Pain -- Spinal Cord Phospholipase A2 and Prostanoids in Pain Processing -- MAP Kinase and Cell Signaling in DRG Neurons and Spinal Microglia in Neuropathic Pain -- Microglia and Trophic Factors in Neuropathic Pain States -- The Cathepsin S/Fractalkine Pair: New Players in Spinal Cord Neuropathic Pain Mechanisms.
  note: edited by Marzia Malcangio.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Neurology
  subject:
    topic: Pain medicine
  subject:
    topic: Neurobiology
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Neurology
  subject:
    topic: Pain Medicine
  subject:
    topic: Neurobiology
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781441902269
  identifier: http://dx.doi.org/10.1007/978-1-4419-0226-9
  record info:
    record creation date: 110414
    record change date: 20151204175525.0
    record identifier: 978-1-4419-0226-9