rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    non sort: The
    title: Role of Genetics in Breast and Reproductive Cancers
  name:
    name part: Welcsh, Piri.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 344 p. 27 illus. online resource.
  abstract: Of all factors contributing to breast cancer, family history of disease is the most powerful. Currently, our understanding of genetic predisposition to breast cancer includes three classes of genes as defined by their associated risks. BRCA1 and BRCA2 are high-penetrance breast cancer predisposition genes. Since the cloning of BRCA1 and BRCA2, inherited mutations in an additional 8 genes, all of which are functionally related to BRCA1 and/or BRCA2, have been shown to variously confer a low-intermediate increased breast cancer risk. Furthermore, recent genome-wide association studies have uncovered eight common variants associated with low-penetrance breast cancer predisposition. Despite these discoveries, most of the familial risk of breast cancer remains unexplained. The Role of Genetics in Breast and Reproductive Cancers is divided into three parts: Recognition of Hereditary Breast and Reproductive Cancer Syndromes, Genetic etiology of breast and reproductive cancers, and Genes and the environment. In the first section, we discuss how genetic counselors and clinicians acknowledge hereditary breast and reproductive cancer syndromes, with an emphasis on the challenges and responsibilities of counseling women in understanding the role of family history in dictating personal cancer risk. This section includes a detailed discussion of the current recommendations for clinical management of women with inherited mutations in BRCA1 and BRCA2. Section II focuses on the impact of inherited mutations in known breast cancer genes on the etiology of breast and reproductive cancers, and the challenges of determining cancer risk when genetic testing reveals variants of unknown consequence in BRCA1 and BRCA2. Because the cellular function of BRCA2 has so elegantly been revealed, we devote a chapter to the current understanding of BRCA2 function and how loss of function contributes to disease development. In addition, we present a discussion of genetic modifiers of risk of BRCA1- a…
  table of contents: Recognition of Hereditary Breast and Reproductive Cancer Syndromes -- Cancer Genetics in the Clinic: The Challenges and Responsibilities of Counseling and Treating Women at Risk -- Management of Women with Inherited BRCA1 and BRCA2 Mutations -- Genetic etiology of breast and reproductive cancers -- Unclassified Variants in the Breast Cancer Susceptibility Genes BRCA1 and BRCA2 -- Recent Advances in Understanding the Cellular Functions of BRCA1 -- Recent Advances in Understanding the Cellular Functions of BRCA2 -- Genetic Modifiers of Risk of BRCA1- and BRCA2-Related Breast and Ovarian Cancers -- Other Hereditary Breast Cancer Syndromes and Genes -- Ovarian and Endometrial Cancer in Patients with Hereditary Non-polyposis Colorectal Cancer Syndrome -- Somatic Alterations and Implications in Breast Cancer -- Somatic Genetic Development in Epithelial Ovarian Cancer -- Genes and the environment -- High-Frequency Low-Penetrance Alleles -- Host and Viral Genetics and Risk of Cervical Cancer -- Estrogen-Metabolizing Gene Polymorphisms, Genetic Susceptibility, and Pharmacogenomics -- The Future of Discoveries in Breast and Reproductive Cancers: The Genome and Epigenetics.
  note: edited by Piri Welcsh.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Oncology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Human Genetics
  subject:
    topic: Oncology
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Cancer Genetics
  identifier: 9781441904775
  identifier: http://dx.doi.org/10.1007/978-1-4419-0477-5
  record info:
    record creation date: 100301
    record change date: 20151125142213.0
    record identifier: 978-1-4419-0477-5