rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Cell-Extracellular Matrix Interactions in Cancer
  name:
    name part: Zent, Roy.
    role:
      role term: editor.
  name:
    name part: Pozzi, Ambra.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    edition: 1.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 314 p. With 1 4-page color insert. online resource.
  abstract: Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
  table of contents: The Extracellular Matrix: An Overview -- Integrin Structure and Function -- Cancer in Context: Importance of the Tumor Microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and Their Receptors in Cancer -- Vitronectin-Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.
  note: edited by Roy Zent, Ambra Pozzi.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Pharmacology
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Cell Biology
  subject:
    topic: Pharmacology/Toxicology
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781441908148
  identifier: http://dx.doi.org/10.1007/978-1-4419-0814-8
  record info:
    record creation date: 100301
    record change date: 20151125161255.0
    record identifier: 978-1-4419-0814-8