rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Muscle Gene Therapy
  name:
    name part: Duan, Dongsheng.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 275 p. online resource.
  abstract: Muscle disease represents an important health threat to the general population. For thousands of years, a cure has been deemed extremely remote, if not impossible, for many relentless muscle diseases such as Duchenne muscular dystrophy. The cloning of muscle disease genes and the prospect of introducing the normal gene to diseased muscle by gene therapy finally bring the hope of a cure. Tremendous progress has been made chasing the muscle gene therapy dream over the past two decades. Valuable information is scattered in the literature. This book represents the first compilation specifically dedicated to issues related to muscle gene therapy. It offers a much needed, up-to-date overview and perspective on the current strategies and status of muscle gene therapy. It covers the cutting edge development of a variety of fascinating strategies such as exon-skipping, AAV gene therapy, RNAi and stem cell approaches. With contributions from prominent investigators in the field, it provides a framework to translate bench science to clinical practice in the upcoming years. This book is a must-have for anyone who is interested in muscle gene therapy including established investigators, clinicians, post-doctoral fellows, graduate students, funding agencies, patients and their families and friends.
  table of contents: Animal Models for Inherited Muscle Diseases -- In Utero Muscle Gene Transfer -- Gene Therapy for the Respiratory Muscles -- Muscular Dystrophy Gene Therapy in Small Animal Models -- Antisense-Mediated Exon Skipping for Duchenne Muscular Dystrophy -- Systemic Treatment of Duchenne Muscular Dystrophy by Antisense Oligomer-Induced Exon Skipping -- RNAi Therapy for Dominant Muscular Dystrophies and Other Myopathies -- Combinatorial Gene Therapy Strategies for Treating Muscular Dystrophies -- Duchenne Cardiomyopathy Gene Therapy -- Systemic Gene Delivery for Muscle Gene Therapy -- Modulating Immune Responses in Muscle Gene Therapy -- Delivering Large Therapeutic Genes for Muscle Gene Therapy -- Muscle as a Metabolic Factory for Gene Therapy -- Muscle as a Target for Genetic Vaccine -- Combining Stem Cells and Exon Skipping Strategy to Treat Muscular Dystrophy -- Gene Therapy Clinical Trials for Muscular Dystrophies.
  note: edited by Dongsheng Duan.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Immunology
  subject:
    topic: Virology
  subject:
    topic: Developmental biology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Developmental Biology
  subject:
    topic: Immunology
  subject:
    topic: Virology
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781441912077
  identifier: http://dx.doi.org/10.1007/978-1-4419-1207-7
  record info:
    record creation date: 100301
    record change date: 20151125161333.0
    record identifier: 978-1-4419-1207-7