rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Melanocortins: Multiple Actions and Therapeutic Potential
  name:
    name part: Catania, Anna.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XX, 153 p. online resource.
  abstract: It is clear that the melanocortins are of immense academic interest. Further, these molecules have remarkable potential as pharmaceutical agents for treatment of multiple human and veterinary disorders and diseases. The evidence to support academic interest and clinical applications lies in significant part within the chapters of this book, chapters written by noted experts in the field who have worked diligently to understand the molecules and to move them toward clinical applications. I personally believe that the - MSH molecule and its derivatives will be used as routine therapeutics in the very near future. My belief is so strong that I left academia to form a company based on -MSH analogs and have caused millions of dollars to be spent on melanocortin research. Now why would a sane professor pick up such a challenge and enter business, an essential step toward any clinical application? It is the - MSH story that drove me. Consider that - MSH occurs in exactly the same amino acid sequence in humans and in the sea lamprey, an organism unchanged since its appearance during the Pennsylvanian period of the Paleozoic era (about 300 million years ago—way before dinosaurs were to be considered). There is unpublished evidence that the stability of the molecule can be traced back a half billion years. Frankly, I believe that the molecule existed even when single cells began to live together.
  table of contents: Structure-Activity Relationships (SAR) of Melanocortin and Agouti-Related (AGRP) Peptides -- Melanocortin Signalling Mechanisms -- Distribution and Function of Melanocortin Receptors within the Brain -- Drugs, Exercise, and the Melanocortin-4 Receptor— Different Means, Same Ends: Treating Obesity -- Melanocortins in Brain Inflammation: The Role of Melanocortin Receptor Subtypes -- Melanocortins and the Cholinergic Anti-Inflammatory Pathway -- Melanocortin Control of Cell Trafficking in Vascular Inflammation -- Terminal Signal: Anti-Inflammatory Effects of ?-Melanocyte-Stimulating Hormone Related Peptides Beyond the Pharmacophore -- Protective Effects of Melanocortins in Systemic Host Reactions -- Development of ?-Melanocortin Analogs for Melanoma Prevention and Targeting -- MSH Radiopeptides for Targeting Melanoma Metastases -- Applications of the Role of ?-MSH in Ocular Immune Privilege.
  note: edited by Anna Catania.
  subject:
    topic: Medicine
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Experimental Medicine and Biology, 681
  identifier: 9781441963543
  identifier: http://dx.doi.org/10.1007/978-1-4419-6354-3
  record info:
    record creation date: 110110
    record change date: 20150519192331.0
    record identifier: 978-1-4419-6354-3