rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: BetaSys
    sub title: Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
  name:
    name part: Booß-Bavnbek, Bernhelm.
    role:
      role term: editor.
  name:
    name part: Klösgen, Beate.
    role:
      role term: editor.
  name:
    name part: Larsen, Jesper.
    role:
      role term: editor.
  name:
    name part: Pociot, Flemming.
    role:
      role term: editor.
  name:
    name part: Renström, Erik.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2011
    edition: 1.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XX, 556 p. online resource.
  abstract: The insulin secreting β-cell is one of the most specialized cell types with diverse and multi-functional components (genes, gene products, organelles and metabolites) and a multitude of regulatory strategies in response to internal and environmental signals. This book looks at the technological advances that make simultaneous detection of thousands of biological variables possible; at a substantial variety of mathematical models and numerical simulations that aim to explain major aspects of the β-cell function; and at the challenge to formulate a comprehensive and robust model of the main networks of the underlying biochemical and physical processes for diagnostic and therapeutic use.
  table of contents: Preface -- Systems biology of β-cells - revisited -- Established facts and open questions of the focused systems analysis of regulated exocytosis in β-cells – a background for a focused systems analysis approach -- Mitochondria and metabolic signals in β-cells -- β-cell ontogenesis and the insulin production apparatus -- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic β-cells -- The mathematical microscope making the inaccessible accessible -- Magnetic resonance imaging of pancreatic β-cells -- Mapping the β-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches -- In vivo applications of inorganic nanoparticles -- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts -- Bioimpedance spectroscopy -- DNA variations, impaired insulin secretion and type-2 diabetes -- Genetically programmed defects in β-cell function -- Proteomic analysis of the pancreatic islet β-cell secretory granule: current understanding and future opportunities -- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes -- Present state of islet transplantation for type-1 diabetes patients -- Predictive protein networks and identification of drugable targets in the β-cell -- Nanotoxicity -- From silicon cell to silicon human -- Probing cellular dynamics with mesoscopic simulations -- What drives calcium oscillations in β-cells? new tasks for cyclic analysis -- Whole-body and cellular models of glucose-stimulated insulin secretion -- Geometric and electromagnetic aspects of fusion pore making -- Index.
  note: edited by Bernhelm Booß-Bavnbek, Beate Klösgen, Jesper Larsen, Flemming Pociot, Erik Renström.
  subject:
    topic: Life sciences
  subject:
    topic: Human genetics
  subject:
    topic: Diabetes
  subject:
    topic: Bioinformatics
  subject:
    topic: Systems biology
  subject:
    topic: Life Sciences
  subject:
    topic: Systems Biology
  subject:
    topic: Human Genetics
  subject:
    topic: Bioinformatics
  subject:
    topic: Diabetes
  classification: QH301-705
  classification: 570
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Systems Biology ; 2
  identifier: 9781441969569
  identifier: http://dx.doi.org/10.1007/978-1-4419-6956-9
  record info:
    record creation date: 110301
    record change date: 20151125201852.0
    record identifier: 978-1-4419-6956-9