rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Histamine in Inflammation
  name:
    name part: Thurmond, Robin L.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVIII, 143 p. online resource.
  abstract: The year 2010 marks the centennial for the identification of histamine and the first glimpse of its many physiological functions. From these initial findings a rich tapestry of research has uncovered roles for histamine in almost every physiological process with new findings emerging every year. These diverse roles of histamine have made for fertile ground for the discovery of novel therapeutics, and these drugs have been so successful that the term “antihistamine” has entered the common lexicon. This volume is an attempt to give a snapshot in time as to the current understanding of the role of histamine in just one important therapeutic area—inflammation. The first three chapters provide some background context for the rest of the book starting out with a historical perspective by Figueroa and Shankley. Bongers et al provide an overview of the pharmacology of the four histamine receptors and the chapter by Hiroshi Ohtsu describes how histamine is synthesized as well as the insights derived from mice where this synthesis is disrupted. The next several chapters discuss disease areas where histamine is known to be involved. Chapter 4 by Thomas Taylor-Clark outlines the role of histamine in allergic rhinitis, an area were antihistamines are commonly used. This is also true for ocular allergy as discussed by Ohbayashi et al. Both of these chapters highlight aspects of these conditions that are still not well-controlled and suggest the utility of new antihistamines targeting other histamine receptors.
  table of contents: One Hundred Years of Histamine Research -- Molecular Pharmacology of the Four Histamine Receptors -- Histamine Synthesis and Lessons Learned from Histidine Decarboxylase Deficient Mice -- Histamine in Allergic Rhinitis -- The Role of Histamine in Ocular Allergy -- The Role of Histamine in Asthma -- Antihistamines in the Treatment of Urticaria -- Histamine and Antihistamines in Atopic Dermatitis -- Histamine, Immune Cells and Autoimmunity -- Histamine in Neurotransmission and Brain Diseases -- Histamine in Normal and Malignant Cell Proliferation -- The Future Antihistamines: Histamine H3 and H4 Receptor Ligands.
  note: edited by Robin L. Thurmond.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Biomedicine
  subject:
    topic: Biomedicine general
  subject:
    topic: Human Physiology
  classification: R-RZ
  classification: 610
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Experimental Medicine and Biology, 709
  identifier: 9781441980564
  identifier: http://dx.doi.org/10.1007/978-1-4419-8056-4
  record info:
    record creation date: 110628
    record change date: 20150519174507.0
    record identifier: 978-1-4419-8056-4