rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: p53
  name:
    name part: Ayed, Ayeda.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Hupp, Theodore.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 200 p. 59 illus., 3 illus. in color. online resource.
  abstract: Our understanding of human cancer in the past 40 years has been driven by linking innovative concepts and cutting edge technologies to key problems identified by clinical research. Some of the successes in cancer genetics identified from clinical work have been the identification of specific gene deletions in human chromosomes, the use of PCR-based cloning methodologies to identify and clone human cancer genes, the validation of the human cancer genes using transgenetic technologies in the mouse, and the ability to sequence whole genomes that has recently allowed a collation of all somatic and germline mutations in a human genome. In the same generation, entirely different disciplines involved in basic life science research have used model organisms like yeast, flies, worms, and cancer causing animal viruses as tools to develop windows to see into the machinery of the cell life cycle. The discoveries of pro-apoptotic genes, oncogenes, and covalent control mechanisms like phosphorylation and ubiquitination using the tools of science and technology have all been awarded Nobel prizes for their contribution to our understanding of how cells work. The discovery of p53 using the tumor causing animal virus SV40 falls into this pioneering period of biological and medical research.
  table of contents: TP53 Mutations in Human Cancers: Selection versus Mutagenesis -- Lessons on p53 from Mouse Models -- TP63, TP73: The Guardian’s Elder Brothers -- The Regulation of p53 Protein Function by Phosphorylation -- The p53-Mdm2 Loop: A Critical Juncture of Stress Response -- Cooperation between MDM2 and MDMX in the Regulation of p53 -- Regulation and Function of the Original p53- Inducible p21 Gene -- p53 Localization -- Modes of p53 Interactions with DNA in the Chromatin Context -- p53’s Dilemma in Transcription: Analysis by Microarrays -- Tumor Viruses and p53 -- p53 and Immunity.
  note: by Ayeda Ayed, Theodore Hupp.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Molecular Biology Intelligence Unit, 1
  identifier: 9781441982315
  identifier: http://dx.doi.org/10.1007/978-1-4419-8231-5
  record info:
    record creation date: 110713
    record change date: 20151126001125.0
    record identifier: 978-1-4419-8231-5