rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Controlled Release in Oral Drug Delivery
  name:
    name part: Wilson, Clive G.
    role:
      role term: editor.
  name:
    name part: Crowley, Patrick J.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2011
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 414 p. online resource.
  abstract: Controlling the rate, extent and time of a drug’s delivery can optimize its performance in many ways, relative to “immediate release” delivery. Such optimized design requires a broad knowledge base of topics such as gastro intestinal tract physiology, polymer science, and the mechanisms by which drugs are released from the formulated units. Technologies to “reduce to practice” also need to be carefully considered. Such knowledge must be allied to the physico chemical properties of the drug, its pharmacokinetic behaviors, enzyme susceptibility and other factors that can affect absorption or timecourse in the biosystem. Traditionally, controlled release systems tended to be “second-generation products, building on accumulated clinical experience. However, better awareness of the molecular biology of drug action and the promise of biomarkers and personalized medicine may mean that optimizing performance by controlling release may become a first option in new product development. Such optimization may well help reduce the alarming attrition rates that are now prevalent in new drug development. Controlled Release in Oral Drug Delivery provides chapters, dealing with all facets of the above subject matter, and its challenges. Authors have been drawn from academia, providers of excipients and from those designing controlled release systems in industrial R&D and manufacture. The contents provide a unique blend of cutting edge knowledge, data on materials and practical experiences. It is essential text for students, researchers and industrial engineering, formulation and manufacturing technologists as well as quality testing and control functions. Clive Wilson is the J. P. Todd Professor of Pharmaceutics at Strathclyde University in Glasgow, Scotland and the current president of the European Union Federation for Pharmaceutical Sciences. He is the Chief Scientist of Bio-Images Research Group, a Phase II imaging specialist clinical unit in Glasgow Royal Infirmary. Major areas …
  table of contents: Introduction and History of Controlling Drug Release -- The Organization of the Gut and the Oral Absorption of Drugs: Anatomical, Biological and Physiological Considerations in Oral Formulation Development -- Controlling Drug Release in Oral Product Development Programs: An Industrial Perspective -- Animal Model Systems Suitable for Controlled Release Modeling -- In Vitro Testing of Controlled Release Dosage Forms during Development and Manufacture -- Oral Controlled Delivery Mechanisms and Technologies -- Drug-Polymer Matrices for Extended Release -- Ion Exchange Approaches to Controlling Drug Release -- Pulsatile Delivery for Controlling Drug Release -- Ordered Mesoporous Silica for the Delivery of Poorly Soluble Drugs -- Geometric Release Systems: Principles, Mechanisms, Kinetics, Polymer Science, Release Modifying Materials -- Extrudable Technologies for Controlling Drug Release and Absorption -- Coated Multiparticulates for Controlling Drug Release -- Capsules as a Delivery System for Modified Release Products -- Lipids in Oral Controlled Release Drug Delivery -- Buccal Drug Delivery -- Controlling Release by Gastro Retention -- Drug Delivery to the Colon.
  note: edited by Clive G. Wilson, Patrick J. Crowley.
  subject:
    topic: Medicine
  subject:
    topic: Pharmaceutical technology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmaceutical Sciences/Technology
  classification: RS380
  classification: RS190-210
  classification: 615.19
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Delivery Science and Technology
  identifier: 9781461410041
  identifier: http://dx.doi.org/10.1007/978-1-4614-1004-1
  record info:
    record creation date: 110920
    record change date: 20150519184454.0
    record identifier: 978-1-4614-1004-1