http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Concepts, Molecular Mechanisms, and Biomedical Applications
XXI, 748 p. 237 illus., 129 illus. in color. online resource.
This book presents a comprehensive molecular theory of the living cell based on over thirty concepts, principles and laws imported from thermodynamics, statistical mechanics, quantum mechanics, chemical kinetics, informatics, computer science, linguistics, semiotics, and philosophy. The author formulates physically, chemically and enzymologically realistic molecular mechanisms to account for the basic living processes such as ligand-receptor interactions, protein folding, single-molecule enzymic catalysis, force-generating mechanisms in molecular motors, signal transduction, regulation of the genome-wide RNA metabolism, morphogenesis, the micro-macro coupling in coordination dynamics, the origin of life, and the mechanisms of biological evolution itself. Possible solutions to basic and practical problems facing contemporary biology and biomedical sciences have been suggested, including pharmacotheragnostics and personalized medicine.
Part I Principles, Laws, and Concepts -- Physics -- Chemistry -- Biology -- Engineering -- Linguistics, Semiotics, and Philosophy -- Part II Theories, Molecular Mechanisms, and Models -- Molecular Mechanisms of Enzymic Catalysis -- The Conformon -- Intracellular Dissipative Structures (IDSs) -- The Living Cell -- Part III Applications: From Molecules to Mind and Evolution -- Subcellular Systems -- Whole Cells -- Mechanisms of the Origin of Life -- Principles and Mechanisms of Biological Evolution -- Multicellular Systems -- What Is Life?- Why Is the Cell So Complex?- Ribonoscopy and Personalized Medicine -- Ribonoscopy and ‘Theragnostics’ -- Application of the Knowledge Uncertainty Principle to Biomedical Sciences -- Conclusions.