rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Systems Biology of Apoptosis
  name:
    name part: Lavrik, Inna N.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XII, 204 p. online resource.
  abstract: Apoptosis is highly defined programmed cell death, which leads to the elimination of cells. Deregulation of programmed cell death is associated with serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. In recent years, apoptosis has been successfully studied using a systems biology approach. Systems biology is a novel field of science which combines mathematical modeling with experimental data leading to predictions of biological processes. The development of this field in recent years is fascinating. Studies of apoptosis using systems biology have provided novel insights into the quantitative regulation of cell death. In Systems Biology of Apoptosis, contemporary systems biology studies devoted to cell death signaling both from experimental and modeling sides is discussed, as well as a focus on how systems biology helps to understand life/death decisions made in the cell and the development of new approaches to rational treatment strategies.
  table of contents: Preface -- Modeling formalisms in systems biology of apoptosis -- Systems biology of death receptor-induced apoptosis -- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis -- Systems Biology of the Mitochondrial Apoptosis Pathway -- Systems biology of cell death in hepatocytes -- Understanding different types of cell death using Systems Biology -- Modeling Single Cells in Systems Biology -- Cytokine-cytokine crosstalk and cell-death decisions -- Genetic and genomic dissection of apoptosis signaling -- Index.
  note: edited by Inna N. Lavrik.
  subject:
    topic: Life sciences
  subject:
    topic: Systems biology
  subject:
    topic: Apoptosis
  subject:
    topic: Life Sciences
  subject:
    topic: Systems Biology
  subject:
    topic: Apoptosis
  subject:
    topic: Biomedicine general
  classification: QH301-705
  classification: 570
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461440093
  identifier: http://dx.doi.org/10.1007/978-1-4614-4009-3
  record info:
    record creation date: 120913
    record change date: 20151125191349.0
    record identifier: 978-1-4614-4009-3