http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
XXVI, 695 p. 61 illus., 40 illus. in color. online resource.
Mesenchymal Stromal Cell (MSC) biology has been studied for more than 4 decades and the cells have been investigated for potential clinical applications for more than 15 years. Progress has become exponential over the past decade due mainly to the broad therapeutic potential of these cells. However, MSC studies have also been subject to controversy and increasing scrutiny as new mechanisms of action are reported and ever-expanding therapeutic applications pursued. In this book, leading authorities from all over the world, who are actively involved in this field, provide state-of-the-art knowledge of the basic biology, translational requirements and latest clinical experience with MSCs. This cutting edge book is the ideal resource for scientists and clinicians interested in pursuing an important and rapidly developing field of research that will eventually help patients and address urgent unmet medical needs. Features include: Coverage of the biology of MSCs, latest understanding of mechanisms of action, and role in tissue homeostasis and regeneration Identifying the potential of MSCs in proceeding from bench to bedside from regulatory , GMP production, ethical and safety aspects Critical analysis of clinical studies and the potential of MSCs to treat a wide variety of human diseases and tissues. .
MSCs in regenerative medicine: A perspective -- MSCs: Changing hypotheses, paradigms, and controversies on mechanisms of action in repairing tissues -- MSCs: the need to rethink -- Characterization of MSCs: From early studies to the present -- MSCs as therapeutics -- MSC niche for hematopoiesis -- Immunomodulatory properties of MSCs -- MSCs and the innate immune system: A balancing act -- MSCs: paracrine effects -- Cross-talk between MSCs and their environments -- Human MSCs from bone marrow, umbilical cord blood and adipose tissue: all the same? -- MSCs in solid tumors and hematological malignancies: from basic biology to therapeutic potential -- MSC studies in large animal Models -- Defining the potential of MSCs with a prenatal large animal Model -- Bench-to-bedside development of MSC based therapies: A multidisciplinary approach -- GMP production of MSCs -- MSCs: The USA regulatory perspective -- MSCs: Clinical applications and European regulatory aspects -- Stem cell treatments around the world: boon or bane? -- Safety issues in MSC therapy -- In Vivo imaging of MSCs -- National Heart, Lung, and Blood Institute support of cellular therapies regenerative medicine -- MSC therapy of inborn errors -- MSCs for enhancement of hematopoietic progenitor cell engraftment and poor graft function -- MSCs for graft-versus-host disease -- MSCs in paediatric hematopoietic stem cell transplantation -- MSCs for ex vivo expansion of umbilical cord blood cells -- MSCs for autoimmune disorders -- MSCs for induction of solid organ allograft acceptance -- MSCs for gastrointestinal disorders -- MSCs for cardiac repair -- MSCs for acute lung injury -- MSCs for diabetes -- MSCs for renal repair -- MSCs for the treatment of stroke, spinal cord injury, and traumatic brain injury: From bench work to clinical trials -- MSCs in reconstructive surgery -- MSCs in orthopedic surgery -- Adipose tissue derived MSCs: Moving to the clinic.
edited by Peiman Hematti, Armand Keating.
Stem Cell Biology and Regenerative Medicine