rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: E-Cell System
    sub title: Basic Concepts and Applications
  name:
    name part: Arjunan, Satya Nanda Vel.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Dhar, Pawan K.
    role:
      role term: author.
  name:
    name part: Tomita, Masaru.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: 179 p. online resource.
  abstract: The interdisciplinary field of molecular systems biology aims to understand the behavior and mechanisms of biological processes composed of individual molecular components. As we gain more qualitative and quantitative information of complex intracellular processes, biochemical modeling and simulation become indispensable not only to uncover the molecular mechanisms of the processes, but to perform useful predictions. To this end, the E‑Cell System, a multi‑algorithm, multi‑timescale object‑oriented simulation platform, can be used to construct predictive virtual biological systems. Gene regulatory and biochemical networks that constitute a sub‑ or a whole cellular system can be constructed using the E‑Cell System to perform qualitative and quantitative analyses. The purpose of E‑Cell System: Basic Concepts and Applications is to provide a comprehensive guide for the E‑Cell System version 3 in terms of the software features and its usage. While the publicly available E‑Cell Simulation Environment version 3 User's Manual provides the technical details of model building and scripting, it does not describe some of the underlying concepts of the E‑Cell System. The first part of the book addresses this issue by providing the basic concepts of modeling and simulation with the E‑Cell System.
  table of contents: Introduction to Whole Cell Modeling -- Foundations of E‑Cell Simulation Environment Architecture -- Distributed Cell Biology Simulations with the E‑Cell System -- A Guide to Modeling Reaction‑Diffusion of Molecules with the E‑Cell System -- A Model Library of Bacterial Chemotaxis on E‑Cell System -- Electrophysiological Simulation of Developmental Changes in Action Potentials of Cardiomyocytes -- Simulation of Human Erythrocyte Metabolism -- Dynamic Kinetic Modeling of Mitochondrial Energy Metabolism -- A Computational Model of the Hepatic Lobule -- Decoding the Signaling Mechanism of Toll‑Like Receptor 4 Pathways in Wild Type and Knockouts -- Modeling of Hsp70‑Mediated Protein Refolding.
  note: by Satya Nanda Vel Arjunan, Pawan K. Dhar, Masaru Tomita.
  subject:
    topic: Medicine
  subject:
    topic: Molecular biology
  subject:
    topic: Biomedicine
  subject:
    topic: Molecular Medicine
  subject:
    topic: Biomedicine general
  classification: QH506
  classification: 611.01816
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Molecular Biology Intelligence Unit
  identifier: 9781461461579
  identifier: http://dx.doi.org/10.1007/978-1-4614-6157-9
  record info:
    record creation date: 150519
    record change date: 20151125191920.0
    record identifier: 978-1-4614-6157-9