rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular Genetics of Pancreatic Cancer
  name:
    name part: Simeone, Diane M.
    role:
      role term: editor.
  name:
    name part: Maitra, Anirban.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: V, 235 p. online resource.
  abstract: Pancreatic cancer is a formidable disease, and advances in early detection and improved therapeutics have been slow to come forth. With new advances in molecular genetics in the field of pancreatic tumorigenesis, it is an opportune time to use these recent discoveries to enhance our understanding of pancreatic cancer biology and to improve outcomes in patients. In this volume, leading experts in the field shed light on these findings describing the mutational landscape of pancreatic cancer, including new inroads into our understanding of familial pancreatic cancer, epidemiology, the biology of K-ras signaling, and the emerging contribution of epigenetic alterations to disease initiation and progression. The distinctive pancreatic cancer-stroma ecosystem as determined by the dynamic interplay of inflammation, hallmark mutations, EMT, and cancer stem cells is described, and implications of these interactions in the context of development of novel, personalized therapeutic options are explored.
  table of contents: Genomic Alterations in Sporadic Pancreatic Cancer -- Molecular Pathology of Pancreatic Cancer Precursor Lesions -- Genetic Epidemiology and Pancreatic Cancer -- Translational Implications of Molecular genetics for Early Diagnosis of Pancreatic Cancer -- The Biology of K-Ras Signaling Pathways in Pancreatic Cancer -- Molecularly Targeted Therapies in Pancreatic Cancer -- Mouse Models of Pancreatic Cancer -- Genetics of Pancreatic Cancer Metastasis -- Epigenetic Alterations in Pancreatic Cancer -- New technologies in Molecular Characterization of Pancreatic Cancer -- Index.
  note: edited by Diane M. Simeone, Anirban Maitra.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Cell Biology
  subject:
    topic: Human Genetics
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461465492
  identifier: http://dx.doi.org/10.1007/978-1-4614-6549-2
  record info:
    record creation date: 130405
    record change date: 20151103131927.0
    record identifier: 978-1-4614-6549-2