rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Human Interphase Chromosomes
    sub title: Biomedical Aspects
  name:
    name part: Yurov, Yuri B.
    role:
      role term: editor.
  name:
    name part: Vorsanova, Svetlana G.
    role:
      role term: editor.
  name:
    name part: Iourov, Ivan Y.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVII, 216 p. online resource.
  abstract: The beginning of interphase cytogenetics can be attributed to significant advances in human molecular genetics and cytogenetics. Owing to experimental and theoretical research at the interface between cellular and molecular levels of chromosomal organization and function, high-resolution techniques for chromosomal analysis (molecular cytogenetic techniques) have become available. Molecular cytogenetics is a branch of biomedical sciences that explores chromosomes at molecular and single-cell resolutions at all stages of the cell cycle. It also comprises the techniques that operate with either the entire genome or specific DNA sequences to analyze genomic structural and functional variations at chromosomal level. In postgenomic era, molecular cytogenetics has appreciably transformed and has given rise to a new field of genomics, called cytogenomics. As a result, new opportunities have emerged for analysis of human interphase chromosomes in almost all cell types and states at unprecedented resolution. In Human Interphase Chromosomes, the editors have provided an overview of current developments in the study of human interphase chromosomes with a special attention to available molecular cytogenetictechnologies for basic and clinical chromosome research.
  table of contents: Introduction. The view on human interphase chromosomes in postgenomic era -- Interphase chromosome behavior in normal and diseased cells -- Nuclear architecture, chromosome domains and genetic damage -- Interphase chromosome of the human brain: the biological and clinical meaning of neural aneuploidy -- Differentiating chromosome fragmentation and premature chromosome condensation -- Chromosomes and nuclear organization in ICF Syndrome -- Interphase cytogenetics at the earliest stages of human development -- Organization of chromosomes in human sperm nucleus -- Interphase chromosome-specific multicolor banding -- Chromosome architecture studied by high resolution FISH-banding in three dimensionally preserved human interphase nuclei -- Technological solutions in human interphase cytogenetics -- Appendix: Molecular cytogenetics and interphase chromosomes on the internet -- Index.
  note: edited by Yuri B. Yurov, Svetlana G. Vorsanova, Ivan Y. Iourov.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Cytogenetics
  subject:
    topic: Cell biology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Cytogenetics
  subject:
    topic: Cell Biology
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461465584
  identifier: http://dx.doi.org/10.1007/978-1-4614-6558-4
  record info:
    record creation date: 130403
    record change date: 20151125201018.0
    record identifier: 978-1-4614-6558-4