rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Human Immunodeficiency Virus Reverse Transcriptase
    sub title: A Bench-to-Bedside Success
  name:
    name part: LeGrice, Stuart.
    role:
      role term: editor.
  name:
    name part: Gotte, Matthias.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 361 p. online resource.
  abstract: The Reverse Transcriptase (RT) of Human Immunodeficiency Virus Type 1 (HIV-1) arguably ranks amongst one of the most extensively studied retroviral enzymes. Heterologous expression and purification of HIV-1 RT in the early eighties, approval of the first nucleoside analogue RT inhibitor (NRTI) in 1987, discovery of resistance to RT inhibitors, approval of the first non-nucleoside analogue RT inhibitor (NNRTI) in 1996 and the various crystal structures of RT with and without bound substrate(s) and/or inhibitors represent only a few of the important milestones that describe the a bench-to-bedside success in the continuing effort to combat HIV-1 infection and its consequences. Nucleoside and nonnucleoside RT inhibitors remain important components in frequently used drug regimens to treat the infection. RT inhibitors also play important roles in recently validated strategies to prevent transmission of the virus. The relevance of HIV-1 RT as a drug target has simultaneously triggered interest in basic research studies aimed at providing a more detailed understanding of interactions between proteins, nucleic acids, and small molecule ligands in general terms. In light of the ever-growing knowledge on structure and function of HIV-1 RT, this enzyme serves as a valuable “model system” in efforts to develop novel experimental tools and to explain biochemical processes. This monograph is designed to provide an overview of important aspects in past and current HIV-1 RT research, with focus on mechanistic aspects and translation of knowledge into drug discovery and development. The first section includes chapters with emphasis placed on the coordination of the RT-associated DNA polymerase and ribonuclease H (RNase H) activities. The second covers mechanisms of action and future perspectives associated with NRTIs and NNRTIs, while the third section includes chapters focusing on novel strategies to target the RT enzyme. Chapters of the final part are intended to discuss mechanism…
  note: edited by Stuart LeGrice, Matthias Gotte.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Virology
  subject:
    topic: Infectious diseases
  subject:
    topic: Biomedicine
  subject:
    topic: Virology
  subject:
    topic: Infectious Diseases
  subject:
    topic: Immunology
  classification: QR355-502
  classification: 616.9101
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461472919
  identifier: http://dx.doi.org/10.1007/978-1-4614-7291-9
  record info:
    record creation date: 130722
    record change date: 20151218153346.0
    record identifier: 978-1-4614-7291-9