rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Epigenetics and Complex Traits
  name:
    name part: Naumova, Anna K.
    role:
      role term: editor.
  name:
    name part: Greenwood, Celia M.T.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXII, 341 p. 43 illus., 33 illus. in color. online resource.
  abstract: Epigenetics and Complex Traits provides an overview of basic epigenetic phenomena that influence transmission of genetic traits, including the pivotal roles of epigenetic factors in genome integrity, genetic transmission and phenotypic variation at critical developmental points, interactions between epigenetic marks and genetic variation, as well as a detailed examination of how epigenetic considerations can alter interpretation and analysis of risks for complex traits. Included in this book are several overviews of the impact of inter-individual variation in epigenetic states, from major changes that cause congenital developmental defects to subtle changes and their impact on complex traits. In addition, there are chapters examining the relationship between epigenetic changes and genetic changes in human disease, methods for statistical analysis of epigenetics effects in human disease genetic studies or in population genetics, and a consideration of how epigenetics influences inheritance and analysis of inheritance. Epigenetics and Complex Traits is a resource for those who are working in mammalian genetics or analysis of human genetic data and are interested in the impact of epigenetics on inheritance. .
  table of contents: Part I: Epigenetic phenomena in the germ line and early embryonic development and their effects on the inheritance of genetic traits -- Epigenetic reprogramming in the mammalian germ line -- Establishment of tissue-specific epigenetic states during development -- X-chromosome Inactivation -- Cis- and trans-effects underlying polar overdominance at the callipyge locus -- Transgenerational epigenetic effects and complex inheritance patterns -- Autosomal monoallelic expression -- Part II: Epigenetic variation in health and disease -- Recurrent CNVs in the etiology of epigenetic neurodevelopmental disorders -- Impact of the early-life environment on the epigenome and behavioral development -- Interaction between genetics and epigenetics in cancer -- Part III: Impact of epigenetics on complex trait genetics and analysis -- Epigenetic variation, phenotypic heritability, and evolution -- Statistical Approaches for Detecting Transgenerational Genetic Effects in Humans -- Transmission ratio distortion: a neglected phenomenon with many consequences in genetic analysis and population genetics -- Epigenome Wide Association Studies: Potential insights into human disease -- Analytical Considerations for Epigenome-wide Association Scans of Complex Traits -- Index. .
  note: edited by Anna K. Naumova, Celia M.T. Greenwood.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Developmental biology
  subject:
    topic: Statistics
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Developmental Biology
  subject:
    topic: Statistics for Life Sciences, Medicine, Health Sciences
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461480785
  identifier: http://dx.doi.org/10.1007/978-1-4614-8078-5
  record info:
    record creation date: 130917
    record change date: 20150520194940.0
    record identifier: 978-1-4614-8078-5