rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Molecular Genetics of Inflammatory Bowel Disease
  name:
    name part: D'Amato, Mauro.
    role:
      role term: editor.
  name:
    name part: Rioux, John D.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 343 p. 23 illus. in color. online resource.
  abstract: Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn’s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
  table of contents: Part 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli” -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index.
  note: edited by Mauro D'Amato, John D Rioux.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Molecular biology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Molecular Medicine
  subject:
    topic: Biomedicine general
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781461482567
  identifier: http://dx.doi.org/10.1007/978-1-4614-8256-7
  record info:
    record creation date: 131004
    record change date: 20151204161724.0
    record identifier: 978-1-4614-8256-7