rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Diabetic Cardiomyopathy
    sub title: Biochemical and Molecular Mechanisms
  name:
    name part: Turan, Belma.
    role:
      role term: editor.
  name:
    name part: Dhalla, Naranjan S.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIX, 416 p. 64 illus., 38 illus. in color. online resource.
  abstract: Diabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease. Diabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardio…
  table of contents: Cardiac defects in diabetes -- Hormonal imbalance and neuropathy -- Role of oxidative stress -- Role of cation channel defects -- Abnormalities in glucose transport -- Fatty acid utilization -- Sarcolemmal Na+-K+ ATPase -- Sarcolemmal Ca2+-transport -- Sarcoplasmic reticular Ca2+-transport -- Intracellular Ca2+-homeostasis -- Mitochondrial function -- Contractile proteins -- β-adrenoceptor mechanisms -- Protein kinases and signal transduction -- Regulation of phopholipases -- Endothelin defects and cardiac dysfunction -- Metabolic changes in smooth muscles -- Metabolic defects in skeletal muscles -- Metabolic defects in brain -- Role of microangiopathy in heart dysfunction -- Role of nephropathy in heart dysfunction -- Prevention of diabetic-induced cardiac dysfunction -- Molecular targets for the therapy of diabetic cardiomyopathy.
  note: edited by Belma Turan, Naranjan S. Dhalla.
  subject:
    topic: Life sciences
  subject:
    topic: Human physiology
  subject:
    topic: Cardiology
  subject:
    topic: Diabetes
  subject:
    topic: Medical biochemistry
  subject:
    topic: Proteomics
  subject:
    topic: Cell membranes
  subject:
    topic: Life Sciences
  subject:
    topic: Proteomics
  subject:
    topic: Diabetes
  subject:
    topic: Cardiology
  subject:
    topic: Human Physiology
  subject:
    topic: Membrane Biology
  subject:
    topic: Medical Biochemistry
  classification: QD431-431.7
  classification: 572.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Biochemistry in Health and Disease ; 9
  identifier: 9781461493174
  identifier: http://dx.doi.org/10.1007/978-1-4614-9317-4
  record info:
    record creation date: 140108
    record change date: 20151204154534.0
    record identifier: 978-1-4614-9317-4