rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Tumor-Induced Immune Suppression
    sub title: Mechanisms and Therapeutic Reversal
  name:
    name part: Gabrilovich, Dmitry I.
    role:
      role term: editor.
  name:
    name part: Hurwitz, Arthur Andrew.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2014
    edition: 2nd ed. 2014.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 464 p. 38 illus., 34 illus. in color. online resource.
  abstract: Tumor-Induced Immune Suppression - Prospects and Progress in Mechanisms and Therapeutic Reversal presents a comprehensive overview of large number of different mechanisms of immune dysfunction in cancer and therapeutic approaches to their correction. This includes the number of novel mechanisms that has never before been discussed in previous monographs. The last decades were characterized by substantial progress in the understanding of the role of the immune system in tumor progression. Researchers have learned how to manipulate the immune system to generate tumor specific immune response, which raises high expectations for immunotherapy to provide breakthroughs in cancer treatment. It is increasingly clear that tumor-induced abnormalities in the immune system not only hampers natural tumor immune surveillance, but also limits the effect of cancer immunotherapy. Therefore, it is critically important to understand the mechanisms of tumor-induced immune suppression to make any progress in the field and this monograph provides these important insights.
  table of contents: Preface.- Regulatory T Cells and Cancer -- Th17 cells in cancer -- Mast cells and immune response in cancer -- Myeloid-Derived Suppressor Cells in Tumor-Induced T-Cell Suppression and Tolerance -- Immunobiology of Dendritic Cells in Cancer -- Macrophages and Tumor Development -- Angiogenesis and Immune Suppression in Cancer -- Tim-3 Regulation of Cancer Immunity.- Transcriptional Regulation of Dendritic Cells in The Tumor Microenvironment -- S100A9, Inflammation, and Regulation of Immune Suppression in Cancer -- IDO in Inflammatory Programming and Immune Suppression in Cancer -- Defining the Fate and Function of Effector T cells through Galectin-1 – Galectin-1 Ligand Binding Interactions: Implications in Tumor Immunity -- Arginine Metabolism, a Major Pathway for the Suppressive Function of Myeloid-derived Suppressor Cells.- The Hypoxia-Adenosinergic Immunosuppression and Redirection of Immune Response in Tumor Microenvironment -- Molecular Pathways in Antigen Presenting Cells Involved in the Induction of Antigen-Specific T-Cell Tolerance -- Overcoming Immune Suppression: Therapeutic Strategies Targeting T-Cell Function in Cancer -- Index.
  note: edited by Dmitry I. Gabrilovich, Arthur Andrew Hurwitz.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Human genetics
  subject:
    topic: Immunology
  subject:
    topic: Medical microbiology
  subject:
    topic: Cell biology
  subject:
    topic: Developmental biology
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Immunology
  subject:
    topic: Medical Microbiology
  subject:
    topic: Cell Biology
  subject:
    topic: Human Genetics
  subject:
    topic: Developmental Biology
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781489980564
  identifier: http://dx.doi.org/10.1007/978-1-4899-8056-4
  record info:
    record creation date: 140210
    record change date: 20151204155710.0
    record identifier: 978-1-4899-8056-4