rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Amorphous Solid Dispersions
    sub title: Theory and Practice
  name:
    name part: Shah, Navnit.
    role:
      role term: editor.
  name:
    name part: Sandhu, Harpreet.
    role:
      role term: editor.
  name:
    name part: Choi, Duk Soon.
    role:
      role term: editor.
  name:
    name part: Chokshi, Hitesh.
    role:
      role term: editor.
  name:
    name part: Malick, A. Waseem.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXII, 699 p. 206 illus., 141 illus. in color. online resource.
  abstract: This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future. .
  table of contents: 1 Fundamentals of Amorphous Systems: Thermodynamic Aspects -- 2 Theoretical Considerations in Developing Amorphous Solid Dispersions -- 3 Overview of Amorphous Solid Dispersion Technologies -- 4 Excipients for Amorphous Solid Dispersions -- 5 Miniaturized Screening Tools for Polymer and Process Evaluation -- 6 HME for Solid Dispersions: Composition and Design Considerations -- 7 HME for Solid Dispersions: Scale up and Late Stage Development -- 8 Spray Drying: Scale UP and Manufacturing -- 9 Design and Development of HPMCAS based spray dried dispersions -- 10 MBP Technology: Composition and Design Considerations -- 11 MBP Technology: Process Development and Scale up -- 12 Pharmaceutical Development of MBP Solid Dispersions: Case Studies -- 13 Downstream Processing Considerations -- 14 Structural Characterization of Amorphous Solid Dispersions -- 15 Dissolution of Amorphous Solid Dispersions: Theory and Practice -- 16 Stability of Amorphous Solid Dispersion -- 17 Regulatory Considerations in Development of Amorphous Solid Dispersions -- 18 KinetiSol® based Amorphous Solid Dispersions -- 19 Amorphous Solid Dispersion Using Supercritical Fluid Technology -- 20 Supersolubilization by Using Non-Salt Forming Acid-Base Interaction -- 21 Stabilized Amorphous Solid Dispersions with Small Molecule Excipients -- 22 Mesoporous ASD – Fundamentals -- 23 Mesoporous Silica Drug Delivery Systems.
  note: edited by Navnit Shah, Harpreet Sandhu, Duk Soon Choi, Hitesh Chokshi, A. Waseem Malick.
  subject:
    topic: Medicine
  subject:
    topic: Pharmaceutical technology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmaceutical Sciences/Technology
  classification: RS380
  classification: RS190-210
  classification: 615.19
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Advances in Delivery Science and Technology
  identifier: 9781493915989
  identifier: http://dx.doi.org/10.1007/978-1-4939-1598-9
  record info:
    record creation date: 141121
    record change date: 20150520190535.0
    record identifier: 978-1-4939-1598-9