rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Humanized Mice for HIV Research
  name:
    name part: Poluektova, Larisa Y.
    role:
      role term: editor.
  name:
    name part: Garcia, J. Victor.
    role:
      role term: editor.
  name:
    name part: Koyanagi, Yoshio.
    role:
      role term: editor.
  name:
    name part: Manz, Markus G.
    role:
      role term: editor.
  name:
    name part: Tager, Andrew M.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXI, 538 p. 54 illus., 45 illus. in color. online resource.
  abstract: Over the last several years the field of humanized mice has matured and developed into an essential component of translational research for HIV/AIDS. Humanized mice serve both as vehicles for discovery and as highly sophisticated platforms for biomedical research. In addition, humanized mice have demonstrated outstanding potential for the investigation of critical aspects of the infection and pathogenesis of the hepatitis and herpes viruses, as well as highly relevant microbial infections such as tuberculosis and malaria. Humanized Mice for HIV Research provides a comprehensive presentation of the history, evolution, applications, and current state of the art of this unique animal model. As an expansion of twelve review articles that were published in Humanized Mice by Springer in 2008 (Eds: Nomura T, Watanabe T, Habu S), this book expertly captures the outstanding progress that has been made in the development, improvement, implementation, and validation of humanized mouse models. The first two parts of this book cover the basics of human-to-mouse xenotransplantation biology, and provide critical information about human immune cell development and function based on individual models created from different immunodeficient strains of mice. The third and fourth parts investigate HIV-1 biology, including different routes of transmission, prevention, treatment, pathogenesis, and the development of adaptive immunity in humanized mice. The fifth part shows the broad applicability of humanized mice for therapeutic development, from long-acting antiretroviral combinations to genetic manipulations with human cells and cell-based approaches. The sixth part includes liver tissue engineering and the expansion of humanized mice for many other human cell-tropic pathogens. About the Editors The Editors have well-documented track records in each of the subject areas covered, including HIV neuropathogenesis and therapeutics (Larisa Y. Poluektova, University of Nebraska Medical Cente…
  table of contents: Mamoru Ito's Vision for the Future of Humanized Mouse Models -- Part I. Mouse genetic background and human hematopoietic stem cells biology -- Humanized Mice as Models for Human Disease -- Role of mouse innate immunity in immunodeficient mice for xenotransplantation -- Mouse genetic background and human hematopoietic stem cells biology; tips for humanization -- Biology of Human Hematopoietic Stem Cell Xenotransplantation in Mice -- Impact of the mouse IL-2Rg chain on lymphoid tissue development and human reconstitution in immunodeficient mice -- BM hematopoietic niche occupancy defect of HSC in scid mice -- Improvement of human multilineage hematopoietic engraftment by cytokine knockin replacement in human-hemato-lymphoid system mice -- Part II. SECTION 2: Understanding of human immune cells development and function in mouse environment -- Cytokine species-specificity and humanized mice -- Human T cell biology in a mouse environment -- Thymic education of human T cells and regulatory T cell development in humanized mice -- Human B cell development in a mouse environment -- The analysis of the functions of human B and T cells in humanized NOG mice -- NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis -- Maintenance and function of human CD8+ T cells and NK cells in humanized mice -- Phenotypical and functional properties of antigen-presenting cells derived from humanized mice -- Part III: Humanized mice for HIV-1 virus biology and pathogenesis. Is it possible to address? -- Humanized mouse versus non-human primate models of HIV-1 infection -- Host factor-mediated resistance to HIV-1 infection -- Vaginal and Rectal HIV Transmission in Humanized Mice -- Oral HIV-1 Transmission in BLT Humanized Mice -- Selective infection of CD4+ memory T cells -- Development and function of human CD4+CD25+FOXP3+ regulatory T cells in humanized mouse and HIV-1 infection -- Role of TLR signaling in HIV-1-induced adaptive immune activation -- Latent H…
  note: edited by Larisa Y. Poluektova, J. Victor Garcia, Yoshio Koyanagi, Markus G. Manz, Andrew M. Tager.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Medical microbiology
  subject:
    topic: Virology
  subject:
    topic: Biomedicine
  subject:
    topic: Medical Microbiology
  subject:
    topic: Immunology
  subject:
    topic: Virology
  classification: QR46
  classification: 616.9041
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781493916559
  identifier: http://dx.doi.org/10.1007/978-1-4939-1655-9
  record info:
    record creation date: 150218
    record change date: 20151204190414.0
    record identifier: 978-1-4939-1655-9