rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Genomic Elements in Health, Disease and Evolution
    sub title: Junk DNA
  name:
    name part: Felekkis, Kyriacos.
    role:
      role term: editor.
  name:
    name part: Voskarides, Konstantinos.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2015
    edition: 1st ed. 2015.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 315 p. 40 illus., 34 illus. in color. online resource.
  abstract: This book provides a thorough review of various non-coding genomic elements and discusses in depth their role in health, disease and evolution. It begins with an exploration of non-coding RNA molecules miRNAs, piRNAs, LncRNAs and transposable elements as these moieties dominate the scientific literature the last ten years. The second part of the book discusses copy number variation regions, mini and micro satellites, and proximal and distal elements of the genome. The last section of the book focuses on the review of well-known non-coding regions of the genome, introns, centromeres and telomeres, but enriched with newly discovered functions. As the vast amount of data in regards to these elements is attributed to a great degree to the growing technology in the field of biomedicine, the last chapter of the book discusses the latest development in the field of Next Generation Sequence and the potential applications of this technology in the study of non-coding regions of the genome. This new volume provides an in depth background on ‘junk DNA’ and helps set the stage for future research, and is an essential tool for those in the field.
  table of contents: MicroRNAs' function and role in evolution -- MicroRNAs and disease -- piRNAs: Transposon silencing and germ line development.-Long non-coding cRNAs -- Unveiling transposable elements function to enrich knowledge for human physiology and disease pathogenesis -- Copy number variation in human health, disease and evolution -- Mini- and micro-satellite markers in health, disease and evolution -- Intron biology, focusing on group II introns, the ancestors of spliceosomal introns.- Centromeres in health, disease and evolution.- Structure and functions of telomeres in organismal homeostasis and disease.- Proximal regulatory elements with emphasis on CpG rich regions.- Genomic analysis through high-throughput sequencing.
  note: edited by Kyriacos Felekkis, Konstantinos Voskarides.
  subject:
    topic: Medicine
  subject:
    topic: Human genetics
  subject:
    topic: Cell biology
  subject:
    topic: Developmental biology
  subject:
    topic: Biomedicine
  subject:
    topic: Human Genetics
  subject:
    topic: Cell Biology
  subject:
    topic: Developmental Biology
  classification: RB155-155.8
  classification: QH431
  classification: 611.01816
  classification: 599.935
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781493930708
  identifier: http://dx.doi.org/10.1007/978-1-4939-3070-8
  record info:
    record creation date: 150930
    record change date: 20151204164542.0
    record identifier: 978-1-4939-3070-8