rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Combination Cancer Therapy
    sub title: Modulators and Potentiators
  name:
    name part: Schwartz, Gary K.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2005
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 284 p. online resource.
  abstract: Early clinical trials of the new molecular-based anticancer agents have shown that many are marginal in controlling cancer, but prove to be potent modulators and potentiators of chemotherapy-induced apoptosis when used in combination with classic cytotoxic drugs or radiation. In Combination Cancer Therapy: Modulators and Potentiators, expert physician-scientists and clinicians with first-hand experience in the clinical development of targeted therapies review those combinations that hold the most promise for the future of medical oncology, detailing their optimal sequence, pharmacokinetic interactions, and interaction with downstream cellular signals. The combinations run the gamut of targeted therapies against cell surface receptors (EGF-R and HER2), the cell cycle (the CDKs), signal transduction events (PKC and NF-kB), apoptosis (bcl-2), as well as focused therapies in ovarian cancer, hematologic diseases, and breast cancer. The authors emphasize novel translational approaches that are rapidly moving from the laboratory benchtop to the patient's bedside as a new generation of cancer therapeutics. Cutting-edge and forward-looking, Combination Cancer Therapy: Modulators and Potentiators offers everyone in the fields of cancer drug development and therapy a powerful new understanding of the optimal sequencing and scheduling of new combination drug therapies necessary to maximize the effects for cancer patients today.
  table of contents: Targeting of the EGFR As a Modulator of Cancer Chemotherapy -- Cyclin-Dependent Kinase Inhibitors in Combination Chemotherapy -- Development of Protein Kinase C and Cyclin-Dependent Kinase Inhibitors As Potentiators of Cytotoxic Drug Action in Leukemia -- Carboxyamidotriazole, an Inhibitor of Nonvoltage-Operated Calcium Entry -- Targeted ?-Particle Therapy -- Pharmacological Modulation of Fluoropyrimidines -- Development of Inhibitors of HER2 With Taxanes -- Targeting NF-?B to Increase the Activity of Cisplatin in Solid Tumors -- Combinations of Chemotherapy and G3139, an Antisense Bcl-2 Oligonucleotide -- Use of Animal Models to Evaluate Signal Transduction Inhibitors As Modulators of Cytotoxic Therapy.
  note: edited by Gary K. Schwartz.
  subject:
    topic: Medicine
  subject:
    topic: Oncology
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Oncology
  classification: RC254-282
  classification: 616.994
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Cancer Drug Discovery and Development
  identifier: 9781592598649
  identifier: http://dx.doi.org/10.1385/1592598641
  record info:
    record creation date: 100301
    record change date: 20150519191455.0
    record identifier: 978-1-59259-864-9