rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Transgenic and Knockout Models of Neuropsychiatric Disorders
  name:
    name part: Fisch, Gene S.
    role:
      role term: editor.
  name:
    name part: Flint, Jonathan.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2006
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: online resource.
  abstract: Neuroscientists are now establishing meaningful genotype-phenotype relationships for complex neurobehavioral and neuropsychiatric disorders and even creating animal models for these dysfunctions. These developments have made it imperative to know when such transgenic and knockout models are valid for the human disorders they represent. In Transgenic and Knockout Models of Neuropsychiatric Disorders, a panel of leading researchers comprehensively assesses how and whether the genetic abnormalities produced from these models manifest the neuropsychiatric disorders to which they correspond. The authors focus on transgenic and knockout models of neurocognitive dysfunction and neuropsychiatric dysfunction. The discussion of neurobiological problems covers mental retardation, polyglutamate, as well as speech disorders, and disorders that involve cognitive, social, speech, and language dysfunction. The neuropsychiatric dysfunctions examined include psychosis and schizophrenia, anxiety, depression, and bipolar disorder. Timely introductory articles debate the alleged continuity of species of human and infrahuman behavior (Darwin), the utility of infrahuman animals in understanding human behavior and psychiatric disease, and the suitability of nonhuman models of complex neuropsychiatric dysfunctions involving language. Comprehensive and systematic, Transgenic and Knockout Models of Neuropsychiatric Disorders offers a clear assessment of whether genetic abnormalities produced from infrahuman models manifest the neuropsychiatric disorders to which they correspond in humans and how best they may be used to carry out successful research today.
  table of contents: and Overview -- Transgenic and Knockout Models of Psychiatric Disorders -- Transgenic Mouse Models and Human Psychiatric Disease -- Transgenic and Knockout Mouse Models -- If Only They Could Talk -- Transgenic and Knockout Models of Neurocognitive Dysfunction -- Spinocerebellar Ataxia Type 1 -- Mouse Models of Hereditary Mental Retardation -- How Can Studies of Animals Help to Uncover the Roles of Genes Implicated in Human Speech and Language Disorders? -- Animal Models of Autism -- Transgenic and Knockout Models of Neuropsychiatric Dysfunction -- Genetic Mouse Models of Psychiatric Disorders -- Animal Models of Psychosis -- Animal Models of Anxiety -- Modeling Human Anxiety and Depression in Mutant Mice -- Mutant Mouse Models of Bipolar Disorder.
  note: edited by Gene S. Fisch, Jonathan Flint.
  subject:
    topic: Medicine
  subject:
    topic: Neurosciences
  subject:
    topic: Biomedicine
  subject:
    topic: Neurosciences
  classification: RC321-580
  classification: 612.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Contemporary Clinical Neuroscience
  identifier: 9781597450584
  identifier: http://dx.doi.org/10.1007/978-1-59745-058-4
  record info:
    record creation date: 100301
    record change date: 20150519184853.0
    record identifier: 978-1-59745-058-4