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Evidence and Analysis in Clinical Neurology
Evidence-based medical practice stresses the examination of evidence from clinical research as the basis for clinical decision making, rather than relying on unsystematic clinical experience and pathophysiological rationale. In Neuromuscular Disease: Evidence and Analysis in Clinical Neurology, Michael Benatar, MBChB, demonstrates this approach in the case of neuromuscular disease with a critical appraisal of the neurological literature. Writing in a readable, accessible style, the author considers, in detail, a broad range of the published literature relevant not only to questions of treatment, but also to issues of diagnosis and prognosis of neuromuscular disease. Through a series of questions and answers concerning specific neuromuscular disorders, each chapter critiques the best available evidence to illustrate strengths and weaknesses of the data and make the reader aware of the quality of clinical research studies in general. Introductory chapters facilitate this learning process by elucidating the epidemiological and biostatistical issues pertinent to diagnosis, treatment, and prognosis. A broad range of disorders of the anterior horn cell, nerve roots, peripheral nerves, neuromuscular junction, and muscle are critically appraised and discussed. Original and illuminating, Neuromuscular Disease: Evidence and Analysis in Clinical Neurology clarifies the available evidence base for why neurologists practice as they do in neuromuscular disease and suggests a healthy degree of skepticism about claims that are made without supporting evidence.
Methodology -- Basic Principles of Epidemiology and Biostatistics -- Diagnosis -- Treatment -- Prognosis -- Spinal Cord, Anterior Horn Cell, and Nerve Roots -- Amyotrophic Lateral Sclerosis -- Cervical Spondylosis -- Lumbar Spondylosis -- Peripheral Nerve Disease -- Polyneuropathy -- Paraproteinemic Neuropathies -- Vasculitic Neuropathy -- Guillain-Barré Syndrome -- Chronic Inflammatory Demyelinating Polyradiculoneuropathy -- Multifocal Motor Neuropathy -- Inherited Neuropathies -- Carpal Tunnel Syndrome -- Ulnar Neuropathy at the Elbow -- Neuromuscular Junction Disorders -- Myasthenia Gravis -- Lambert-Eaton Myasthenic Syndrome -- Muscle Disease -- Inflammatory Myopathy -- Idiopathic Hyper-CK-emia -- Statin-Induced Myopathy -- Metabolic Myopathy -- Critical Illness Weakness -- Myotonic Dystrophy -- Facioscapulohumeral Muscular Dystrophy.