rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Transforming Growth Factor-β in Cancer Therapy, Volume I
    sub title: Basic and Clinical Biology
  name:
    name part: Jakowlew, Sonia B.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2008
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XXIV, 735 p. online resource.
  abstract: Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide a compendium of findings about the role of transforming growth factor-ß (TGF-ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. Part I presents basic concepts of transforming growth factor-ß signaling in normal physiology and cancer pathobiology. Part II investigates transforming growth factor-ß superfamily members in normal and tumor biology. Part III details transforming growth factor-ß in inflammation and fibrosis. This volume’s companion, Cancer Treatment and Therapy, examines transforming growth factor-ß in several developing and advanced cancers and discusses methods of treatment and therapy. Together, Transforming Growth Factor-ß in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-ß in biology and cancer treatment.
  table of contents: Basic Concepts of TGF-? Signaling in Normal Physiology and Cancer Pathobiology -- Component Hardware for Transforming Growth Factor-? Signal Transduction: TGF-? Ligands, TGF-? Receptors, and Smads -- TGF-? Signaling in Homeostasis and Cancer -- TGF-? Availability: Latent TGF-? and Latent TGF-? Binding Proteins -- Biological Functions of Latent TGF-?-Binding Proteins and Activation of TGF-? -- Regulators of Smad2/3 Transcription and Phosphorylation -- Interaction of Smad4 and Embryonic Liver Fodrin-?-spectrin in Hyperplasia, Neoplasia, and Tumor Suppression -- Regulation of Smad Activity by Phosphorylation -- Nuclear Targeting of TGF-?-Activated Smads in Normal and Tumor Biology -- Ski, SnoN, and Akt as Negative Regulators of Smad Activity: Balancing Cell Death and Cell Survival -- Transforming Growth Factor-? in Cancer Therapy: Smurfs in TGF-? Signaling and Regulation of Bone Homeostasis and Cancer -- Involvement of km23 Dynein Light Chains in TGF ? Signaling -- TGF-? Signaling in Fibroblastic Cells and Oncogenesis -- Mechanisms of TGF-?-Induced Apoptosis in Cancer Cells -- Mechanisms of Cell Cycle Regulation by TGF-? Disabled in Cancer -- Transforming Growth Factor-? in Cancer Therapy -- TGF-? and Smad Signaling in Transcriptome Reprogramming During EMT -- Functional Interactions Between MMPs and TGF-? in Normal and Tumor Tissue -- Cooperation Between TGF-? and Wnt Pathway Components in Regulating Mesenchymal Stem Cell Function -- Interaction of Oncogenic Ras and TGF?1 Signaling in Cancer: Lessons From the Multistage Skin Carcinogenesis Model -- TGF-? Superfamily Members in Normal and Tumor Biology -- Proteomics Analysis of TGF? Superfamily Members -- Mullerian Inhibiting Substance: A Potential Nontoxic, Naturally Occurring Therapeutic Agent for Certain Human Cancers -- Activins, Inhibins, and Bone Morphogenetic Proteins as Modulators and Biomarkers of Prostate Cancer Progression -- Bone Morphogenic Proteins and Angiogenesis in Developing Tumors -- Histone Methyltr…
  note: by Sonia B. Jakowlew.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Pharmacology
  subject:
    topic: Oncology
  subject:
    topic: Cell biology
  subject:
    topic: Medicine & Public Health
  subject:
    topic: Oncology
  subject:
    topic: Cell Biology
  subject:
    topic: Cancer Research
  subject:
    topic: Pharmacology/Toxicology
  classification: RC254-282
  classification: 616.994
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Cancer Drug Discovery and Development
  identifier: 9781597452922
  identifier: http://dx.doi.org/10.1007/978-1-59745-292-2
  record info:
    record creation date: 100301
    record change date: 20151204171152.0
    record identifier: 978-1-59745-292-2