rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Hormesis
    sub title: A Revolution in Biology, Toxicology and Medicine
  name:
    name part: Mattson, Mark P.
    role:
      role term: editor.
  name:
    name part: Calabrese, Edward J.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2010
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIV, 213 p. online resource.
  abstract: Hormesis is defined as any circumstance in which exposure of a cell or organism to a low dose of a substance or condition results in an adaptive stimulatory/beneficial outcome, while exposure to a high dose results in an inhibitory / detrimental outcome. When plotted on a graph the shape of the dose response curve is biphasic, the hallmark of hormesis. This groundbreaking book "Hormesis: A Revolution in Biology, Toxicology and Medicine" describes why and how hormesis is a fundamental feature of all living systems and is based on the evolutionary principle of selection for genetic traits that confer the ability to respond adaptively to adverse environmental conditions. Using numerous specific examples the authors explain why knowledge of hormesis is important for our health, our environment, and the future of our planet. Several chapters of the book describe emerging research findings that elucidate the molecular and cellular underpinnings of the biphasic dose response/hormesis. The implications of the tapping of cellular systems that underlie hormesis for the discovery and optimization of new drugs and dietary formulations are described. From environmental protection policy to medical practice, it is critical that leaders recognize and understand hormesis, and incorporate it into their decision making process. The authors propose that the prevention of major diseases, including diabetes, obesity and cardiovascular disease can be achieved using hormetic approaches. Scientists, physicians, environmental gurus and anyone interested in the science underlying biology and medicine will benefit from reading this book. Features Groundbreaking coverage of an oft experienced, but poorly understood phenomenon that affects all forms of life on earth. Explains why the principle of hormesis is important to our health, our environment, and the future of our planet. Provides specific examples of biphasic dose responses and their importance for the fields of biology, medicine and en…
  table of contents: Hormesis: What it is and Why it Matters -- Hormesis: Once Marginalized, Evidence Now Supports Hormesis as the Most Fundamental Dose Response -- The Fundamental Role of Hormesis in Evolution -- Transcriptional Mediators of Cellular Hormesis -- The Devil is in the Dose: Complexity of Receptor Systems and Responses -- Exercise-Induced Hormesis -- Dietary Energy Intake, Hormesis, and Health -- Couch Potato: The Antithesis of Hormesis -- Hormesis and Aging -- The Hormetic Pharmacy: The Future of Natural Products and Man-Made Drugs in Disease Prevention and Treatment.
  note: edited by Mark P. Mattson, Edward J. Calabrese.
  subject:
    topic: Medicine
  subject:
    topic: Human physiology
  subject:
    topic: Molecular biology
  subject:
    topic: Neurosciences
  subject:
    topic: Pharmacology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Neurosciences
  subject:
    topic: Molecular Medicine
  subject:
    topic: Human Physiology
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781607614951
  identifier: http://dx.doi.org/10.1007/978-1-60761-495-1
  record info:
    record creation date: 100301
    record change date: 20151125162347.0
    record identifier: 978-1-60761-495-1