rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Immunotoxicity, Immune Dysfunction, and Chronic Disease
  name:
    name part: Dietert, Rodney R.
    role:
      role term: editor.
  name:
    name part: Luebke, Robert W.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2012
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVI, 452 p. online resource.
  abstract: Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes,multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students. .
  table of contents: Introduction to Immunotoxicity -- The Environment-Immune Route to Chronic Disease -- Asthma and Respiratory Allergies -- Cutaneous Allergies -- Food Allergies -- Factors Involved in Onset of Type1 Diabetes -- Rheumatoid Arthritis -- Environment, Immune Dysfunction and Systemic Lupus Erythematosus -- Multiple Sclerosis, Alzheimer’s Disease and Inflammation: A Hypothetical View -- Immune Dysfunction in Autism Spectrum Disorders -- Atherosclerosis and Inflammatory Heart Disease -- Inflammatory Bowel Disease and Celiac Disease: Environmental Risks Factors and Consequences -- COPD and Other Inflammatory Diseases of the Lung: Focus on AhR signaling -- Environment, the Immune System, and Depression: An Integrative Review and Discussion of the Infection-Defense Hypothesis -- Cancer – Childhood Acute Leukemia -- Environmental Toxicants and Susceptibility to Infection -- Reducing the Prevalence of Immune-Based Chronic Disease.
  note: edited by Rodney R. Dietert, Robert W. Luebke.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Molecular biology
  subject:
    topic: Pharmacology
  subject:
    topic: Biomedicine
  subject:
    topic: Pharmacology/Toxicology
  subject:
    topic: Immunology
  subject:
    topic: Molecular Medicine
  classification: RM1-950
  classification: 615
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Molecular and Integrative Toxicology
  identifier: 9781617798122
  identifier: http://dx.doi.org/10.1007/978-1-61779-812-2
  record info:
    record creation date: 120604
    record change date: 20151204163655.0
    record identifier: 978-1-61779-812-2