rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Mitochondrial DNA, Mitochondria, Disease and Stem Cells
  name:
    name part: St. John, Justin C.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: X, 190 p. online resource.
  abstract: This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.
  table of contents: Clinical Approach to the Diagnosis of Mitochondrial Disease -- Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease -- Embryonic Stem Cells: A Signalling Perspective -- From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) A Mitochondrial Odyssey -- From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases -- The Role of Mitochondrial DNA in Tumor Cells -- Assisted Reproductive Technologies to Prevent the Transmission of mtDNA from one Generation to the Next.
  note: edited by Justin C. St. John.
  subject:
    topic: Life sciences
  subject:
    topic: Cell biology
  subject:
    topic: Stem cells
  subject:
    topic: Cell physiology
  subject:
    topic: Life Sciences
  subject:
    topic: Stem Cells
  subject:
    topic: Cell Biology
  subject:
    topic: Cell Physiology
  classification: QH588.S83
  classification: 571.6
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Stem Cell Biology and Regenerative Medicine
  identifier: 9781627031011
  identifier: http://dx.doi.org/10.1007/978-1-62703-101-1
  record info:
    record creation date: 120928
    record change date: 20151125221517.0
    record identifier: 978-1-62703-101-1