rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Peroxisome Proliferator-Activated Receptors
    sub title: Discovery and Recent Advances
  name:
    name part: Youssef, Jihan A.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Badr, Mostafa Z.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: xxu
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: IX, 137 p. online resource.
  abstract: All three peroxisome proliferator-activated receptor (PPAR) subtypes share a high degree of structural homology while exhibiting differences in function, tissue distribution, and ligand specificity. In Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances, the authors trace the history of PPAR discovery and detail the receptor structure and its posttranslational modifications. Furthermore, endogenous ligands as well as various classes of exogenous ligands, subtype-selective, dual and pan agonists as well as antagonists, are discussed. In addition, the tissue distribution and versatile functions of PPAR subtypes in major organs are described. As PPARs play critical roles as regulators of numerous physiological as well as pathophysiological pathways, Peroxisome Proliferator-Activated Receptors: Discovery and Recent Advances aims to help researchers to develop safer and more effective PPAR modulators as therapeutic agents to treat a myriad of diseases and conditions.
  table of contents: Introduction.- History of PPAR Discovery: Peroxisomes -- Peroxisomal biogenesis and diseases -- Peroxisome proliferation.- Peroxisome Proliferator-Activated Receptors: Chromosomal location and gene polymorphism -- Protein structure -- PPAR Ligands: Endogenous ligands -- Exogenous PPAR modulators -- Tissue Distribution and Versatile Functions of PPARs: Neurological functions of PPARs.- PPARs and the cardiovascular system.- PPARs in pulmonary physiology and disease.- Gastrointestinal roles of PPARs.- PPAR functions in the liver.- Roles of PPARs in the pancreas.- PPARs in the urinary tract physiology and pathophysiology.- PPARs in the reproductive system -- Bone metabolism and PPARs.- Roles of PPARs in skeletal muscle biology.- Skin PPARs.- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions: Posttranslational control of PPARs.- Mechanism of action.- Animal Models in PPAR Research.- Safety of PPAR Agonists.- The Future of PPAR Research.
  note: by Jihan A. Youssef, Mostafa Z. Badr.
  subject:
    topic: Life sciences
  subject:
    topic: Biochemistry
  subject:
    topic: Proteins
  subject:
    topic: Life Sciences
  subject:
    topic: Biochemistry, general
  subject:
    topic: Receptors
  classification: QH345
  classification: QD415-436
  classification: 572
  related item:
    title info:
      title: Springer eBooks
  identifier: 9781627034203
  identifier: http://dx.doi.org/10.1007/978-1-62703-420-3
  record info:
    record creation date: 130419
    record change date: 20151125151957.0
    record identifier: 978-1-62703-420-3