rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners
  name:
    name part: Davies, Marianne.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: Eaby-Sandy, Beth.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2019
    edition: 1st ed. 2019.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: V, 120 p. 9 illus., 8 illus. in color. online resource.
  abstract: This book aims to educate nurses and advanced practice providers (APP's) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP's are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP's with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on …
  table of contents: Chapter 1. Introduction -- Chapter 2. Introduction to Mutation Testing -- Chapter 3. Nursing Considerations with EGFR inhibitors in NSCLC -- Chapter 4. Nursing Considerations with ALK and ROS1 inhibitors in NSCLC -- Chapter 5. BRAF in Non-Small Cell Lung Cancer -- Chapter 6. Mechanisms of acquired resistance to targeted therapy in NSCLC: Role of Repeat Biopsy and Nursing Considerations -- Chapter 7. The Impact and Toxicity of Checkpoint Inhibitors in Management of Lung Cancer -- Chapter 8. The Role of Anti-Angiogenic Agents (VEGF) -- Chapter 9. Nursing Considerations for Patients Treated with Targeted Therapies.
  note: edited by Marianne Davies, Beth Eaby-Sandy.
  subject:
    topic: Nursing administration
  subject:
    topic: Oncology
  subject:
    topic: Respiratory organs-Diseases
  subject:
    topic: Nursing Management
  subject:
    topic: Oncology
  subject:
    topic: Pneumology/Respiratory System
  classification: RT81.5
  classification: 610.73
  classification: 610.73072
  related item:
    title info:
      title: Springer eBooks
  identifier: 9783030165505
  identifier: https://doi.org/10.1007/978-3-030-16550-5
  record info:
    record creation date: 190716
    record change date: 20191021213003.0
    record identifier: 978-3-030-16550-5