rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Early Life Origins of Ageing and Longevity
  name:
    name part: Vaiserman, Alexander.
    role:
      role term: editor.
    role:
      role term: edt
    role:
      role term: http://id.loc.gov/vocabulary/relators/edt
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2019
    edition: 1st ed. 2019.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XI, 310 p. 27 illus., 17 illus. in color. online resource.
  abstract: This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.
  table of contents: SECTION I OVERVIEW -- Introductory chapter -- SECTION II EXPERIMENTAL STUDY OF DOHAD -- Early Life Programming of Aging in Genetically Long-Lived Mice -- Immunological Basis of In Utero Programming of Adult Disease -- Developmental Programming of the GH/IGF Axis and Long Term Health -- Programming of Stress Responses -- Early-life Nutritional Programming of Adult Health Status -- Effects of In-Utero Conditions on Adult Feeding Preferences -- IUGR-Related Programming of Metabolic Syndrome and Type 2 Diabetes -- Early-life Programming of Osteoporosis -- Developmental Epigenetic Programming of Skeletal Muscle Aging -- Effect of fetal and child health on kidney development and long-term risk of hypertension and kidney disease. -- Developmental Programming of Neuroimmune Function -- Epigenetics and neurodegeneration: role of early-life nutrition -- SECTION III EPIDEMIOLOGICAL EVIDENCE -- Prenatal Undernutrition and Ageing and Longevity -- Influence of Maternal Obesity on the Long-Term Health of Offspring -- Early Life Predictors of Women's Health and Ageing -- Early-Life Predictors of Exceptional Longevity -- Prenatal Undernutrition and Effects on Physical and Mental Health -- Ancestral and early origins of adult mortality - a multigenerational approach -- SECTION IV PERSPECTIVES AND IMPLICATIONS -- Social Policy and Public Health Perspectives of DOHaD: Implications for Policy Advocacy, Cross-Sectorial Collaboration and Health Promotion -- Index.
  note: edited by Alexander Vaiserman.
  subject:
    topic: Aging
  subject:
    topic: Developmental biology
  subject:
    topic: Gene expression
  subject:
    topic: Geriatrics
  subject:
    topic: Biogerontology
  subject:
    topic: Developmental Biology
  subject:
    topic: Gene Expression
  subject:
    topic: Geriatrics/Gerontology
  classification: QH529
  classification: QH491-492
  classification: 571.8
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Healthy Ageing and Longevity, 9
  identifier: 9783030249588
  identifier: https://doi.org/10.1007/978-3-030-24958-8
  record info:
    record creation date: 190729
    record change date: 20190729075720.0
    record identifier: 978-3-030-24958-8