rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Replicating Vaccines
    sub title: A New Generation
  name:
    name part: Dormitzer, Philip R.
    role:
      role term: editor.
  name:
    name part: Mandl, Christian W.
    role:
      role term: editor.
  name:
    name part: Rappuoli, Rino.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: sz
    date issued: 2011
    edition: First.
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XIII, 447 p. online resource.
  abstract: Technological advances, together with a better understanding of the molecular biology of infectious microorganisms, are creating exciting possibilities for a new generation of replicating vaccines. Historically, live vaccines have been either directly derived from a natural source or attenuated by empirical approaches using serial passages and host cell adaptation. Currently, we are witnessing a quantum leap in our technological capabilities to specifically modify the genetic make-up of viruses and bacteria, making it possible to generate improved live vaccines and to develop completely new types of replicating vaccines, such as vectored vaccines, single-round infectious vaccines and replicon vaccines. This book highlights some of the most exciting recent developments towards a new generation of replicating vaccines.
  table of contents: SECTION 1: Today’s Live Attenuated Vaccines -- Live Vaccines and their Role in Modern Vaccinology -- Live Attenuated Vaccines: Influenza, Rotavirus and Varicella Zoster -- Classical Live Viral Vaccines -- SECTION 2: Genetically Attenuated Micro-Organisms as Vaccines -- Recombinant Live Vaccines to Protect Against the Severe Acute Respiratory Syndrome Coronavirus -- Live Attenuated Shigella Vaccines. Is encouraging good enough? -- New generation BCG vaccines -- SECTION 3: Manipulating Host-Pathogen Interactions to Make Vaccines -- Basic Science Paves the Way to Novel Safe and Effective Pestivirus Vaccines -- Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation Approaches -- An Attenuated Herpes implex Virus 1 Live Virus Vaccine Candidate that is Replication Competent but Defective in Epithelial Cell to Cell and Neuronal Spread -- RSV Deletion Mutant – Innate Immunity -- Live Attenuated Cholera Vaccines: Flagella and Reactogenicity -- SECTION 4: New Types of Replicating Vaccines -- Replication-defective Herpes simplex Virus Mutant Strains as Genital Herpes Vaccines and Vaccine Vectors -- Nucleic Acid-Based Infectious and Pseudo-Infectious Flavivirus Vaccines -- Application of Cleavage Activation Mutants of Influenza Virus as Live Vaccines -- Alphavirus Particle-based Vaccine Vectors -- Recombinant, Chimeric, Live, Attenuated Vaccines against Flaviviruses and Alphaviruses.
  note: edited by Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli.
  subject:
    topic: Medicine
  subject:
    topic: Immunology
  subject:
    topic: Medical microbiology
  subject:
    topic: Vaccines
  subject:
    topic: Virology
  subject:
    topic: Biomedicine
  subject:
    topic: Medical Microbiology
  subject:
    topic: Vaccine
  subject:
    topic: Immunology
  subject:
    topic: Virology
  classification: QR46
  classification: 616.9041
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Birkhäuser Advances in Infectious Diseases
  identifier: 9783034602778
  identifier: http://dx.doi.org/10.1007/978-3-0346-0277-8
  record info:
    record creation date: 101109
    record change date: 20151030031121.0
    record identifier: 978-3-0346-0277-8