http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
Untranslated Gene Regions and Other Non-coding Elements
Regulation of Eukaryotic Gene Expression
VIII, 56 p. 2 illus. in color. online resource.
There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
Introduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
by Lucy W. Barrett, Sue Fletcher, Steve D. Wilton.
SpringerBriefs in Biochemistry and Molecular Biology