rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Iron Acquisition by the Genus Mycobacterium
    sub title: History, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development
  name:
    name part: Byers, B. Rowe.
    role:
      role term: editor.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2013
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: V, 92 p. 39 illus., 9 illus. in color. online resource.
  abstract: Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
  table of contents: A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform.
  note: edited by B. Rowe Byers.
  subject:
    topic: Life sciences
  subject:
    topic: Inorganic chemistry
  subject:
    topic: Bioorganic chemistry
  subject:
    topic: Infectious diseases
  subject:
    topic: Proteins
  subject:
    topic: Microbiology
  subject:
    topic: Life Sciences
  subject:
    topic: Microbiology
  subject:
    topic: Protein-Ligand Interactions
  subject:
    topic: Inorganic Chemistry
  subject:
    topic: Bioorganic Chemistry
  subject:
    topic: Infectious Diseases
  classification: QR1-502
  classification: 579
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Molecular Science
  identifier: 9783319003030
  identifier: http://dx.doi.org/10.1007/978-3-319-00303-0
  record info:
    record creation date: 130518
    record change date: 20151103125049.0
    record identifier: 978-3-319-00303-0