rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: SCF and APC E3 Ubiquitin Ligases in Tumorigenesis
  name:
    name part: Inuzuka, Hiroyuki.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: Wei, Wenyi.
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: V, 118 p. 11 illus. in color. online resource.
  abstract: This SpringerBrief explores the physiological roles of Skp1-Cullin1-F-box Complex (SCF) and Anaphase Promoting Complex (APC) in normal cells and in tumor formation. These two related, multi-subunit E3 ubiquitin ligase enzymes, APC and SCF are thought to be the major driving forces governing proper cell cycle progression. Defective cell cycle regulation leads to genomic instability and ultimately, cancer development. Selective degradation of key cell cycle regulators by the ubiquitin-proteasome system has been proven to be a major regulatory mechanism for ensuring ordered and coordinated cell cycle progression. The SCF and APC E3 ligases have been characterized to play pivotal roles in regulating the cell cycle progression by timely degrading various critical cell cycle regulators. This Brief reviews recent studies that have shown that deregulation of signaling pathways in which the two ubiquitin ligases are involved causes aberrant cell cycle regulation, in turn leading to tumorigenesis. The text also discusses how SCF and APC may present promising therapeutic targets to treat various cancers.
  table of contents: 1. Introduction -- 2. The Fbxw subclass of SCF E3 ubiquitin Ligases -- 3. The FbxL subclass of SCF E3 ubiquitin Ligases -- 4. The Fbxo subclass of SCF E3 ubiquitin Ligases -- 5. APC/Cdc20 and APC/Cdh1 E3 ubiquitin Ligases -- 6. Conclusions and Future Perspectives.
  note: by Hiroyuki Inuzuka, Wenyi Wei.
  subject:
    topic: Medicine
  subject:
    topic: Cancer research
  subject:
    topic: Proteins
  subject:
    topic: Cell cycle
  subject:
    topic: Biomedicine
  subject:
    topic: Cancer Research
  subject:
    topic: Cell Cycle Analysis
  subject:
    topic: Protein Structure
  classification: RC261-271
  classification: 614.5999
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: SpringerBriefs in Cancer Research
  identifier: 9783319050263
  identifier: http://dx.doi.org/10.1007/978-3-319-05026-3
  record info:
    record creation date: 140327
    record change date: 20151103124712.0
    record identifier: 978-3-319-05026-3