rdf-syntax-grammar
mods:
  schema location: http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
  title info:
    title: Dissecting Regulatory Interactions of RNA and Protein
    sub title: Combining Computation and High-throughput Experiments in Systems Biology
  name:
    name part: Jens, Marvin.
    role:
      role term: creator
    role:
      role term: author.
  name:
    name part: SpringerLink (Online service)
  type of resource: text
  origin info:
    place:
      place term: gw
    date issued: 2014
    issuance: monographic
  language:
    language term: eng
  physical description:
    form: electronic
    form: electronic resource
    reformatting quality: access
    form: remote
    extent: XVIII, 99 p. 38 illus., 19 illus. in color. online resource.
  abstract: The work described in this book is an excellent example of interdisciplinary research in systems biology. It shows how concepts and approaches from the field of physics can be efficiently used to answer biological questions, and reports on a novel methodology involving creative computer-based analyses of high-throughput biological data. Many of the findings described in the book, which are the result of collaborations between the author (a theoretical scientist) and experimental biologists, and between different laboratories, have been published in high-quality peer-reviewed journals such as Molecular Cell and Nature. However, while those publications address different aspects of post-transcriptional gene regulation, this book provides readers with a complete, coherent and logical view of the research project as a whole. The introduction presents post-transcriptional gene regulation from a distinct angle, highlighting aspects of information theory and evolution, and laying the groundwork for the questions addressed in the subsequent chapters, which concern the regulation of the transcriptome as the primary functional carrier of active genetic information.
  table of contents: Introduction -- Computational analysis of PAR-CLIP data -- Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR -- Binding site occupancy with competition interactions in equilibrium -- Circular RNAs are a large class of animal RNAs with regulatory potency -- Discussion -- Methods.
  note: by Marvin Jens.
  subject:
    topic: Engineering
  subject:
    topic: Gene expression
  subject:
    topic: Biochemistry
  subject:
    topic: Systems biology
  subject:
    topic: Biological systems
  subject:
    topic: Computational intelligence
  subject:
    topic: Engineering
  subject:
    topic: Computational Intelligence
  subject:
    topic: Biological Networks, Systems Biology
  subject:
    topic: Gene Expression
  subject:
    topic: Biochemistry, general
  classification: Q342
  classification: 006.3
  related item:
    title info:
      title: Springer eBooks
  related item:
    title info:
      title: Springer Theses, Recognizing Outstanding Ph.D. Research
  identifier: 9783319070827
  identifier: http://dx.doi.org/10.1007/978-3-319-07082-7
  record info:
    record creation date: 140520
    record change date: 20151103124025.0
    record identifier: 978-3-319-07082-7